What Is Daunorubicin?
Daunorubicin is a kind of actinomycete from the soil of Zhengding County, Hebei Province, China, and proposed a similar substance (ie daunorubicin). It is mainly used for acute lymphocytic or myeloid leukemia that is resistant to commonly used antitumor drugs, but the remission period is short, so it needs to be combined with other drugs. It is orange-red needle-like crystals, easily soluble in water. Its aqueous solution is quite stable and can be stored at 0 ° C or 37 ° C for 3 weeks without changing its vitality. The effect is the same as that of doxorubicin. It is embedded in DNA and can inhibit the synthesis of RNA and DNA. The effect on RNA is particularly obvious and it selectively acts on purine nucleosides.
Basic Information
- Chinese name
- Daunorubicin
- Foreign name
- Daunorubicin
- Drug alias
- Erythromycin, erythromycin
- English alias
- CarloErba, Cerubidin
Daunorubicin indication
- Treatment of acute myeloid and acute lymphoblastic leukemia.
Clinical application of daunorubicin
- 1. Intravenous or drip. Dissolve 10ml saline for injection before use. Intravenous infusion was dissolved with 250ml of 0.9% sodium chloride injection, and the infusion was completed within 1 hour.
- 2. Adults: the dosage is 0.4 1.0mg / kg for one course, children: 1.0mg / kg for one course, once a day for 3 to 5 times, continuously or every other day. Repeat after 1 week of withdrawal. The total dose does not exceed 25 mg / kg.
Daunorubicin adverse reactions
- 1. Bone marrow suppression is more serious, so do not apply medicine for too long. If oral ulcers occur (this reaction usually occurs before bone marrow toxicity), the drug should be discontinued immediately.
- 2. Gastrointestinal reactions: nausea, vomiting, abdominal pain, mouth ulcers.
- 3. Cardiotoxicity: Can cause myocardial damage, abnormal electrocardiogram, arrhythmia, and severe heart failure, so the total amount should not exceed 25mg / kg. Arrhythmias can also occur when the drip is fast.
- 4. Leakage outside the blood vessel can cause local tissue necrosis.
Precautions for daunorubicin
- Use with caution in patients with liver dysfunction. Virus vaccination is prohibited during medication and within 3 to 6 months after discontinuation of this product.
Daunomycin medication contraindications
- Those who are allergic to this product are prohibited. Patients with severe heart disease, severe infection, severe bone marrow suppression, severe liver and kidney dysfunction are disabled. Banned for pregnant and lactating women.
Daunorubicin drug interactions
- It should not be mixed with drugs that are too acidic or alkaline, so as not to reduce the potency or failure. Drugs that are toxic to the heart or liver cannot be used with daunorubicin. This product may have cross-resistance with doxorubicin, but no cross-resistance with cytarabine, methotrexate, cyclophosphamide and nitrosourea.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.