What Is Fucoxanthin?
Fucoxanthin is also known as Fucoxanthin and Fucoxanthin. It is a natural pigment of lutein in carotenoids, accounting for more than 10% of the total amount of approximately 700 naturally occurring carotenoids. The color is light yellow to brown, and it is the pigment contained in brown algae, diatom, gold algae and yellow green algae. It is widely found in various algae, marine phytoplankton, aquatic shellfish and other animals and plants. It has anti-tumor, anti-inflammatory, anti-oxidation, weight loss, nerve cell protection, and increases ARA (arachidonic acid) and DHA (docosahexaenoic acid) content in mice. Products and health products are widely used in the market. [1]
- Fucoxanthin aka Fucoxanthin
- English name: Fucoxanthin
- Alias: 3 '-(Acetyloxy) -6', 7'-didehydro-5,6-epoxy-5,5 ', 6,6', 7,8-hexahydro-3,5'-dihydroxy-8-oxo- beta, beta-carotene
- Product name: Fucoxanthin; 3 '-(acetoxy) -6', 7'-didehydro-5,6-epoxy-5,5 ', 6,6', 7,8-hexahydro -3,5'-dihydroxy-8-oxo-beta
- Molecular formula: C 42 H 58 O 6
- Molecular weight: 658.91
- CAS Number: 3351-86-8 [2]
- Various algae, marine phytoplankton, and aquatic shellfish are widely present.
| [Density]: | 1.1 ± 0.1 g / cm3 |
|---|---|
| [Boiling point]: | 786.5 ± 60.0 ° C at 760 mmHg |
| [Melting point]: | 166-168ºC |
| [Molecular formula]: | C42H58O6 |
| [Molecular weight]: | 676.922 |
| [ Flash point]: | 228.5 ± 26.4 ° C |
| [Exact mass]: | 676.433899 |
| [PSA]: | 96.36000 |
| [LogP]: | 7.70 |
| [Appearance]: | Crystal powder |
| [Vapor pressure]: | 0.0 ± 6.2 mmHg at 25 ° C |
| [Refractive index]: | 1.563 |
- Antitumor effect
- (1) Skin cancer <br /> Fucoxanthin can inhibit the enhancement of mouse epidermal ornithine decarboxylase activity induced by tetradecanoylphorbol-13-acetate (TPA), a strong skin carcinogen. At the same time, it can inhibit the activation of human herpes virus induced by TPA, thereby inhibiting skin tumors induced by TPA.
(2) Colon cancer <br /> Fucoxanthin has an inhibitory effect on duodenal cancer formation induced by N-ethyl-N'-nitro-N-nitrosoguanidine. Fucoxanthin significantly inhibits the growth of colon cancer cell lines, including Caco-2, HT-29 and DLD-1. Induces DNA fragmentation of colon cancer cells, promotes apoptosis, and inhibits the expression of apoptosis-related protein Bcl-2.
Fucoxanthin can dose-dependently inhibit the proliferation of human colon cancer cell line WiDr cells, and can block the cell cycle in the G0 / G1 phase and induce apoptosis.
(3) Hematological tumors <br /> Effects of fucoxanthin on acute myeloid leukemia HL-60 cell line. Fucoxanthin can significantly inhibit the proliferation of HL-60 cells. Effects of Fucoxanthin on Adult T Lymphocytic Leukemia Fucoxanthin and its metabolite fucoxanthin can inhibit the survival of human T-cell lymphotropic virus type 1 (HTLV-1) infected T cells and adult T-cell leukemia cells.
(4) Prostate cancer <br /> Fucoxanthin can significantly reduce the survival rate of prostate cancer cells and induce apoptosis. Fucoxanthin and its metabolite fucoxanthin can inhibit PC-3 cell proliferation, activate Caspase-3, and induce apoptosis.
(5) Liver cancer <br /> Fucoxanthin has an inhibitory effect on the growth of human liver cancer HepG2 cells, can block the cells in the G0 / G1 phase, and inhibits the phosphorylation of the Ser780 site of the Rb protein.
2. Antioxidant effect <br /> Fucoxanthin has good antioxidant effect, even better than vitamin E and vitamin C. Fucoxanthin has protective effects on human fibroblast damage caused by UV-B. Fucoxanthin's antioxidative effect is mainly through the regulation of Na + -K + -ATPase activity and the activity of catalase and glutathione in tissues and molecules caused by retinol deficiency.
3. Anti-inflammatory effect <br /> Fucoxanthin has an inhibitory effect on the exudation of inflammatory mediators induced by endotoxin and has a dose-dependent relationship. Its anti-inflammatory effect is comparable to that of prednisone, indicating that Endotoxin-induced inflammatory infiltration, NO, PGE2 and tumor necrosis factor in mice have some inhibitory effects. Its anti-inflammatory effect is mainly by inhibiting the exudation of NO, an inflammatory response caused by lipopolysaccharide-induced macrophages. RT-PCR analysis shows that the mRNA of NO synthase and cyclooxygenase is inhibited by fucoxanthin, and, Tumor necrosis factor, interleukin IL-1 and IL-6, and mRNA survivin expression are all inhibited by fucoxanthin in a dose-dependent relationship. These results indicate that fucoxanthin may respond to a variety of inflammations Has an important role.
4. Weight Loss <br /> Fucoxanthin can eliminate fat accumulation in two ways. Fucoxanthin activates a protein called UCP1, which promotes lipolysis. It can also stimulate the liver to produce DHA that lowers cholesterol levels.
5. Others < br Sea Urchin Diet Seaweed contains fucoxanthin and has significant effects on the phagocytosis and ovulation of macrophages.
- Fucoxanthin is a natural carotenoid. It is difficult to dissolve in highly polar solvents such as water under neutral conditions, and is easily soluble in non-polar organic solvents. It is a fat-soluble pigment. The extraction of pigments in dry powders is usually performed by adding a small amount of a small polar solvent to a non-polar solvent.
1. Extraction process of fucoxanthin from kelp: Anhydrous ethanol-acetone-petroleum ether (4: 1: 1) composite solvent is used as extraction agent, and the extraction is performed twice at a material-liquid ratio of 40: 1 and 40 ° C. 1h. After the extracted extract was saponified, fucoxanthin and fucosterol were separated and purified by silica gel column chromatography to obtain a high-purity product with a purity of 91.6%.
2. Fucoxanthin extraction process in Sargassum fusiformis: 90% ethanol-acetone (3: 1) composite solvent is used as the extractant, and the liquid-material ratio is 40: 1, the ultrasonic temperature is 65 and the water bath is shaken and extracted twice, each 80min, the extraction rate reached 1.067mg · g-1. Alternatively, fucoxanthin was prepared from kelp root by supercritical CO2 extraction using ethanol as an entrainer, and the purity of the crude extract was 5%. [1]
- 1. In addition to being a weight-loss health product, it can also be applied to various foods, such as butter, pies, green tea crisps and other baked foods, to increase product color and functionality.
2. For egg yolk colorant.
3. Skincare and beauty products.
4. As a medicine, it is used for the treatment of skin cancer, colon cancer, prostate cancer, liver cancer and other cancers. [1]
| Dangerous Goods Sign | F |
| Danger category code | 11 |
| safety instructions | 7-16-24 / 25 |
| Dangerous Goods Transport Number | UN1170-class 3-PG 2-Ethanol, solution |
| Customs code | 29153900 |
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