What is the connection between acetaminophene and the kidneys?
Long -term use or abuse of acetaminophene can cause irreparable kidney damage. Individuals who regularly use acetaminophene to relieve pain according to the instructions are not considered to be the risk of kidney damage. Those who abuse over -the -counter analgesic drugs (OTC) are considered to be the greatest risk of acetaminophene toxicity, which is the accumulation of the drug in the body where it is unable to effectively exclude the kidneys as a counter that is available over the counterattack. When the drug is used as directed, it does not pose any risk for renal or kidney. Normally, the drug works to relieve pain and then filtered by the kidneys and excluded as waste. In cases where the drug is abused or abused, it accumulates in the body. Over time, the kidneys are not able to eliminate the drug at speed sufficient to compensate for its intake. As a result, the toxic levels of acetaminophene and the kesna of the today work cause damage,that can quickly become permanent.
individuals with acetaminophene toxicity can remain asymptomatic for several hours. Symptoms and symptoms of overdose may include nausea, loss of appetite and a general feeling of malaise. It is not uncommon for some people to experience significant abdominal discomfort, jaundice and vomiting. Once the kidney function deteriorates, other symptoms may include dehydration, reduced urination and swelling resulting from the accumulation of fluid in the body. In some cases, the individual may lose consciousness, a medical emergency requiring immediate treatment.
Several factors affect the rate of absorption of acetaminophene and kidney function and subsequent damage that may result. Individuals of advanced age and persons with existing health, including kidney disease, are considered to be the largest toxicity of acetaminophene and kidney damage. Because it is in the liver distributed acetamInofen are also threatened by those who have impaired function or liver disease. The toxicity of acetaminophene primarily affects the kidneys in one of two ways.
If the kidneys suddenly stop functioning normally, acute kidney failure has occurred. Acute kidney failure may develop in just a few hours and contribute to irreversible kidney damage. Those who regularly use acetaminophen for a long time, for example for several months or years, are the greatest risk of the condition known as analgesic nephropathy. Analgesic nephropathy, a form of chronic kidney disease, requires permanent relying on dialysis. Toxic levels of acetaminophene and kidney dysfunction may require kidney transplantation if there has been extensive, irreparable damage.
If acetaminophene is suspected, usually order a test battery. After physical examination, blood and urine analysis, to control the symptoms of acetaminophene toxicity. To evaluate kidney function and determine the scope of whatEven kidney damage can be carried out some imaging tests.
The primary goal of treating toxic levels of acetaminophene and kidneys that are at risk of damage is the flushing of toxin from the body. All use of acetaminophene must be stopped to prevent further toxicity. If acetaminophene has been recently used, coal may be administered to remove any remaining acetaminophene from the digestive tract. The antidote, called n-acetylcysteine (NAC), is administered orally or intravenously to act against the effects of acetaminophene toxicity. If kidney damage is not very significant, it may be perverted by antidotal treatment.
When irreparable kidney damage is suffered, long -term condition is necessary to prevent further deterioration of the organs. Common approaches include food supplements, diuretics and in some Cases, dialysis. Medicines designed to maintain the right potassium and calcium levels in the blood are also administered to prevent further complications associated with ACEtaminophene and kidneys.