What is the connection between cortisone and depression?
The connection between cortisone and depression is that depression is one of the psychological side effects of steroids such as cortisone. Other psychological side effects are irritability, euphoria and agitation. These effects are particularly evident when high doses of steroids are administered and may occur within a few days.
cortison and its derivatives are steroids that are effective anti -inflammatory drugs, often prescribed for neurological, respiratory, rheumatoid and allergic conditions. Although it is popular and strong therapy, steroids are associated with physical and psychological side effects. The connection between depression and cortisone, as well as many other changes in mood, anxiety, behavior disorders and cognitive disorders are poorly understood and poorly defined mainly because of their complexity and unpredictability.
In the past, it was assumed that those who suffered from psychological side effects, mental disorder such as depression and cortisone, this condition simplye worsened. Newer studies, however, have shown that this is not the case and steroids affect the central nervous system in general. As for why this should vary from gentle mood change to full psychosis, it is not yet understood. It has been shown that psychological side effects such as euphoria and hypomania are more likely with short -term treatment and depressive symptoms are more often associated with long -term therapy.
The difficulty in studying the connection between cortisone and depression is reflected in a wide range of results of the study. While some scientists have found that the occurrence of psychiatric side effects related to steroids is below 2%, others said that the occurrence is more than 50%. In analysis of 11 studies, it was found that the average incidence was less than 30%, from mild to serious. It was found that Evere's psychiatric disorders on average less than 6%. Several studies that have been conducted by the investigating response must be children to corticosteroiDy found that almost half of those who received oral cortisone represented adverse psychological effects such as depression and anxiety.
The most important factor in conjunction between cortisone and depression seems to be dosing. The higher the dose, the more likely the appearance of the side effects, most of which occurs at the beginning of the therapy. If cortisone caused mental disorders such as depression, the drug is usually reduced or stopped completely. However, another connection between cortisone and depression is that a rapid or substantial reduction in cortisone can also cause serious changes in the mental state. For this reason, attention and download should be carefully monitored.