What is transdermal buprenorphine?
transdermal buprenorphine is a narcotic drug administered through a time -relaxing local patch. Healthcare providers prescribe buprenorphine for patients suffering from chronic pain that ranges from mild to serious. Buprenorphine is a semi -synthetic opiate that carries high potential for dependence and side effects that are similar to those associated with other narcotic analgesics. The strong binding capacity of buprenorphin on many different opiate receptors causes difficulty in trying to reverse the effects of antagonist opiate drugs that include naloxone.
Laboratories create buprenorphine using alkaloid z papaver somniferum, commonly known as opium poppy. Medicines are chemically similar to codeine and morphine, but are considered 20% to 40% more effective than morphine. Studies show that transdermal buprenorphine acts as a partial agonist at the Delta, MU and ORL1 receptor points in the brain.
drugs stimulating receptors that are responsible for a number of central nervousSystem and hormonal responses, including appetite regulation, endorphin release, stomach motility and mood. These centers also determine drug tolerance and physical dependence. Buprenorphine also acts as an antagonist and blocks Kappa receptor. In addition to natural pain control, this receptor regulates the elimination of fluids through the kidneys and regulates the level of consciousness.
manufacturers produce transdermal buprenorphine in specially laminated patches that provide doses of drugs in 5, 10 or 20 micrograms per hour. Patients generally apply cleaning patch, hairless skin. Upper back, upper chest, upper outer arms and hips of chest are recommended application points and the patient can generally wear patch up to seven days before replacement. Transdermal buprenorphine is also available as a three -day patch in Europe.
healthcare providers normally prescribe transdermal buprenorphine for chRonic pain associated with cancer, osteoarthrosis and neuropathy. Laboratories also produce buprenorphine in solution, for intramuscular or intravenous injection. In addition to its analgesic use, drugs have proved to be effective as opiate detoxification agent. Buprenorfin and naloxone are combined in a sublingual tablet for the treatment of opiate dependence.
The common side effects of buprenorphin are skin irritation associated with the adhesive on the transdermal patch. Directions recommend that patients regularly alternate applications and not repeat the application to the same site for at least 21 days. Other common reactions include nausea, vomiting and dizziness and headaches. The sub -patch or area with the applied heat patch causes increased release of drugs and also increases vascular circulation. These combined actions create potential overdose with buprenorphine overdose.
patients wearing buprenorphin patch can also experience constipation, fluid retention and hypotension. BindThe reactions of the central nervous system include respiratory depression, sedation and change in judgment. Buprenorphine increases the effects of alcohol and over -the -counter medicines or prescription drugs that act as depressions of the central nervous system.