What Is Anti-D Immunoglobulin?

Rh immunoglobulin is used to prevent hemolysis in newborns.

Rh immunoglobulin

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Rh immunoglobulin is used to prevent hemolysis in newborns.

Rh-negative people are stimulated by Rh-positive red blood cells (with Rh antigen) to produce antibodies. Anti-D immunoglobulin can be extracted from their serum. Rh-negative mothers give birth to the first Rh-positive fetus. During the delivery process, the red blood cells of the Rh-positive fetus enter the Rh-negative mother and stimulate the mother to produce IgG anti-Rh antibodies. If the next time a Rh-positive fetus is pregnant, this antibody can enter the fetus through the placenta and may cause hemolytic disease in the newborn. If the Rh-negative mother is injected with 300-400 micrograms (g) of Rh immunoglobulin within 72 hours after the first-born Rh fetus is delivered, it can prevent the fetal Rh-positive red blood cells from sensitizing the mother and prevent the next-born Rh. Positive neonatal hemolysis. Rh immunoglobulin has no obvious preventive effect on mothers who have produced Rh antibodies. In addition, Rh-negative mothers who are pregnant with Rh-positive fetuses should be treated the same after abortion, even if the term is not aborted. Rh-positive fetuses develop Rh-positive red blood cells at about 2 months of embryonic age. Such fetal blood can be sensitized as long as 0.1 to 0.25 ml enters the mother. Therefore, prevention of Rh sensitization should be considered after small or induced abortion.