What are neurofibrillary tangles?
neurofibrillary tangles are found inside the brain cells of people with Alzheimer's disease. They are one of the significant features of Alzheimer's disease, along with the accumulation of protein known as amyloid plaques. At the microscopic level, a neurofibrillary tangle is observed, which consists of a bundle of structures similar to thread called microtubules. These are contaminated with proteins known as Tau proteins. Tau proteins and microtubules usually occur in brain cells, but in humans without Alzheimer's most microtubules, they are mutually parallel and the Tau proteins are properly connected. It is a common disease that affects millions of people around the world and there is no medicine. The brains of people with Alzheimer's disease seem to be reduced compared to the brains of healthy individuals and the spaces or chambers in the brain are larger. Inside the nerve cell of the brain is the classic feature of Alzheimer's presence of neurofibrillary harmful and amyloid plaques or senile plaques. Senile plaques consist of collecting protein found outside noFresh cells in the brain, and although there are healthy elderly people, they are in much larger numbers in Alzheimer's patients.
Within a healthy nerve cell in the brain, microtubules are arranged in straight rows. It serves as a structural framework for the cell, as well as a transport network with which the substances can pass. Tau proteins are part of the connecting structures that hold the microtubules together.
In Alzheimer's disease, Tau proteins deform and can no longer help to support the proper arrangement of microtubules, resulting in the transport network disrupted. Nervous cells no longer have to communicate effectively and are assumed that the inability of the trial Ansport could also contribute to their death later in illness. It is possible to see a neurofibrillary tangle in a human brain without Alzheimer's disease, because they occur in healthy individuals, but in a much smaller number.
Because cells usually haveEffective mechanisms for deprivation of defective proteins, it is not known why the brain cell does not need deformed Tau proteins found within the neurofibrillary fifth. The ongoing research of the function of various proteins involved in the removal of the damaged TAU can help develop a medicine for Alzheimer's disease in the future. So far there are no treatments that are able to erad Senile plaques and neurofibrillary tangles, but there are medicines that can slow down the disease progression for some people.