What are the different causes of haemophilia?

Hemophilia is a health condition in which blood cannot coarse properly and is caused by mutated genes. People who have haemophilia inherit the state through genes and are born with this disease. These people carry mutated genes that produce proteins that cannot do effective work in clotting blood. There are three forms of haemophilia: haemophilia A, B and C. For each type of disease the specific causes of haemophilia are somewhat different. Hemophilia A and B can even cause one to bleed internally without a known reason, in joints and body muscles. All abnormal bleeding is caused by a problem with blood. Blood carries substances called clotting of factors that respond to an open wound by blood cell aggregation and closing the wound, thereby stopping bleeding. People who have haemophilia produce low levels of one of these proteins.

The causes of haemophilia are always abnormal genes. In most cases, abnormal genes come from parents, but sometimes eggs with normal parental gene may be mutated andcause a disease. The causes of haemophilia A and B are mutated genes that are present on X chromosome. Women have two X chromosomes and men have one x chromosome and one chromosome Y.

The presence of haemophilia A or B requires two copies of mutated genes, so much more men than women suffer from illness. In order for a woman to have one of these forms of haemophilia, two x chromosomes with a mutated gene must be inherited and this scenario only occurs when the father of Hemophiliac and the mother bears a mutated gene. The woman more often carries one mutated gene, but the other healthy gene prevents any disease.

In the case of haemophilia and is affected by the factor of the clotting factorviii, or the factor eight. People who have haemophilia A have mutated versions of the gene that produces factor VIII. IX, which is also known as a factor of Nine, is a clotting of protein that is not sufficiently produced in people who have haemophilia B. Both of these mutated genesY - The causes of haemophilia are in most cases placed on X chromosome.

Rarely, haemophilia C may occur. In this particular form of the disease, the affected person has a low level of XI factor or eleven factors. Both women and men may have this condition because the gene for this collision is not located on X or Y chromosome chromosome.