What Are the Symptoms of a Magnesium Overdose?
Hypermagnesemia is a rare biochemical abnormality. Impaired renal function is the main cause of hypermagnesemia. But most of the symptoms of hypermagnesemia are related to the use of magnesium-containing drugs.
- Hypermagnesemia is a rare biochemical abnormality. Impaired renal function is the main cause of hypermagnesemia. But most of the symptoms of hypermagnesemia are related to the use of magnesium-containing drugs.
Causes of hypermagnesemia
- Mainly in patients with renal insufficiency, urinary magnesium excretion is reduced, causing hypermagnesemia. Occasionally during the treatment of eclampsia with magnesium sulfate, hypermagnesemia can occur in mothers and infants. Early burns, extensive injuries or surgical stress, severe extracellular fluid deficiency, and severe acidosis can also cause increased serum magnesium.
Clinical manifestations of hypermagnesemia
- Symptoms and signs of magnesium excess will only occur when the serum magnesium concentration is> 2mmol / L. Main manifestations are fatigue, fatigue, disappearance of tendon reflexes, and decreased blood pressure. When the serum magnesium is further increased, cardiac conduction dysfunction occurs, and the ECG shows that the PR interval is prolonged, the QRS is widened, and the T wave is increased, similar to the changes in the electrocardiogram of hyperkalemia. Respiratory depression, drowsiness and coma, and even cardiac arrest can occur in advanced stages.
Excess magnesium
- Serum magnesium determination should be done for those suspected of hypermagnesemia.
Diagnosis of hypermagnesemia
- Judgment can be made based on medical history, clinical manifestations, and laboratory data.
Hypermagnesia Treatment
- There is a significant antagonism between calcium and magnesium. 10% calcium gluconate 10 20ml or 10% calcium chloride 5 10ml can be infused first to combat the inhibition of magnesium on the heart and muscles. At the same time, acidosis must be actively corrected And lack of water. If serum magnesium does not decrease or symptoms do not decrease, peritoneal dialysis or hemodialysis should be used as soon as possible.