What factors affect the frequency of anemia of sickle cells?

Anemia of sickle cells is a genetic disease characterized by DNA mutations that cause changes in hemoglobin found in red blood cells. The name of anemia of sickle cells comes from a sickle -shaped shape of red blood cells that deal with illness. The disease primarily affects only those individuals whose ancestors came from certain regions such as Africa, Saudi Arabia and some Mediterranean countries. The factors that affect the frequency of anemia of sickle cells include geography, prevalence of malaria and genetics of individuals and recent ancestors.

Because this particular mutation is genetically inherited disease, genetics is the primary factor affecting the frequency of anemia. Both parents must carry a mutation to have a child. Parents may have illness or only carriers of the properties of sickle cells. According to studies, the child born to parents who have both defective Genll anemia and 50 % chance to become a carrier.

geography plays an important role in the frequency of anÉemia of sickle cells. Tropical and subtropical areas, especially Sub -Saharan Africa, have the highest percentage of affected people. For example, in Nigeria it is estimated that up to 40 percent of the population are carriers of a mutated gene. Such rates increase the frequency of anemia of sickle cells, because it is more likely that both parents will have a gene.

While statistics show that some areas of the world have a higher degree of sickle cells, types of anemia of sickle cells observed in some regions differ. For example, the inhabitants of Saudi Arabia and Senegal usually exhibit a milder form of anemia of sickle cells than inhabitants in Africa. Scientists explain these differences because different nations have experienced different spontaneous mutations of the vgens associated with anemia of sickle cells. Historically, the inhabitants of a particular geographical area near the ancestors' homes remained and prevented genetic mutations or the spread of certain types of mutations intoother regions.

In addition to genetics, the largest factor is contributing to the frequency of anemia of sickle cells prevalence of malaria in a particular area. Malaria is caused by a parasite that is located, at least for a certain period of time, in red blood cells. Non -stink cells cannot support parasite and usually die before the parasite can replicate. In many regions, this inherited resistance to malaria provides population built -in defense. Unfortunately, the result is a higher frequency of anemia of sickle cells among the inhabitants, because more people with mutation are able to survive the focus.