What is a cholinergic crisis?
The biochemical phenomenon known as the cholinergic crisis is an episode of excessive stimulation in one of the neuromuscular intersections of the body. Such an event is the result of the accumulation of acetylcholine (ACH) derived from inactivity or insufficiency of acetylcholinesterase. A common cause of cholinergic crisis episodes is the unintended overdose of treatment drugs in patients with myasthenia gravis. Other causes include the exposure of nervous substances and post-surgical overdose of cholinesterase inhibitors designed to reverse residual muscle paralysis. When cholinergic crisis occurs, muscles can no longer respond to the influx of ACH and respiratory failure, flabby paralysis, excessive salivation and sweating are likely to follow. Acholinergic crisis resulting from medication overdose. To identify the actual cause of paralysis, the doctor is likely to perform an Edrophonium drug. People with Myasthenia Gravis who receive this medicine will see that after the introduction of the drug increases the severity of their paralysis if they experience a real cholinergic crisis. NaoThen, if the patient sees an increase in muscle strength after administration of the medicine, it is likely to worsen its basic state. It is important that this type of diagnostic procedure is performed only by an experienced physician prepared for the use of intubation, ventilation and resuscitation techniques if necessary.
As soon as diagnostic testing confirms that the patient actually suffers from cholinergic crisis rather than the myasthenic crisis, there will be standard treatment. Atropine is an accepted antidote when the patient had an overdose of anticholinesterase. It is essential that the suffering myasthenia gravis, who represent this particular diagnostic puzzle and who are commonly subject to medicinal therapy with anticholinesterase, have immediate access to atropin intervention. If the atropine is not administered soon after the beginning of the cholinergic crisis, there may be serious side effects, including severe muscle weakness and possibly respiratory failure leading to death.
ChoThe linergic crisis caused by organophosphate poisoning after the exposure of nerve substances leads to the same types of symptoms as the suffering of myasthenia gravis after treatment overdose. The harmful effects of nerve substances develop when their composite chemicals bind and inefficient and acetylcholinesterase in the body. The result is aggregation of excess ACH at neuromuscular intersections, in accordance with a cholinergic event. The weakness of the muscles, respiratory failure and surplus Sinyion is likely to follow. The protocols of treatment for the crisis caused by nerve agents include body decontamination, clothing and related surfaces, as well as atropin and oxim administration capable of interrupting the bond between the nerve agent and the ACH enzyme.