What Is a Diphtheria Toxin?

Diphtheria toxin is a protein consisting of 535 amino acids, with two subunits in common, and the subunits are connected by disulfide bonds. The molecular weight is 62000 and the isoelectric point pH is 4.1. Containing two disulfide bridges combined with a 14-amino acid ring, the molecule has characteristics of toxicity and specific immunity. Biological missiles (targeted drugs) are commonly used as factors that kill tumor cells.

Diphtheria toxin

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Diphtheria toxin is a protein consisting of 535 amino acids, with two subunits in common, and the subunits are connected by disulfide bonds. The molecular weight is 62000 and the isoelectric point pH is 4.1. Containing two disulfide bridges combined with a 14-amino acid ring, the molecule has characteristics of toxicity and specific immunity. Biological missiles (targeted drugs) are commonly used as factors that kill tumor cells.
Chinese name
Laryngeal toxin
Foreign name
diphtheria toxin
Definition
Exotoxin produced by diphtheria ()
Lead
Myocardial steatosis
Molecular weight
62000
Structure
Polypeptide chain containing two disulfide bonds
Diphtheria toxin can cause demyelination of biological nerves. The length of incubation period for diphtheria toxin infection depends on the dose of infection. In the early stage of diphtheria toxin infection, the cytoplasm of Schwann cells proliferated, the myelin sheath at Lang Fei's nodules eventually fell off the axon, the nodal space widened, and the paramyelin sheath was broken. Subsequently, more myelin was broken, and the distance between Lang Fei knots increased. Degraded myelin is removed by macrophages.
Diphtheria toxin has the effect of inhibiting protein synthesis. By inhibiting translocation, it mainly inhibits protein synthesis in mammals.
Also, it constitutes a "Tabby Heart" in severe cases.

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