What is acetylcystein?
acetylcysteine, also known n-acetylcysteine or NAC, is a by-product of n-acetyly, which is derived from cysteine, amino acid produced by the human body. It is also a precursor of glutathionic synthesis, a strong antioxidant. In medicine, this substance is formulated in acetylcysteine solution containing a concentration of 10 or 20 percent, a buffer by adding diluted disasrocal edent and hydrochloric or sodium hydroxide to achieve a pH of 6.0 to 7.5. Acetylcysteine is prescribed as mucolytic, which means that inhalation helps thin excess mucous membranes in the lungs. However, this compound is also produced in oral and intravenous drugs for consideration of overdose of acetaminophene. In fact, it is believed that this group disrupts disulphide chains, which usually occur in mucus that otherwise enter cell waste by binding to glycoproteins. The effect of this activity is to reduce the viscosity of the mucous membranes, which is less resistant to normal flow and discharge. Because the mucosal viscosity ofMO is related to excessive accumulation of glycoproteins and deoxyribonucleic acid (DNA), acetylcysteine is particularly effective because neither material offers its action.
as inhalation acetylcysteine is useful in the treatment of various respiratory disorders such as bronchitis, pneumonia, tuberculosis and emphysema. Sometimes it is also given to help breathing in surgical patients, while in anesthesia, as well as posryrgically for those who have undergone trachea or trachea procedures. In addition, the drug may be introduced to help in diagnosing respiratory diseases.
As an antidote to the toxicity of acetaminophene, acetylcysteinhepatoPatoPatoral effect develops by reducing the impact of the n-acetyl-p-benzochinone imin (NAQI) accumulation that may result from the reception of large doses of this pain reliever. Toxicity occurs because normal glutathion levels cannot handle overload nApqi, to which it would otherwise be tied and transmitted to the liver to eliminate. Instead, NAQI levels remain free and attack hepatocytes, specialized cells in the liver involved in the regulation of carbohydrates, cholesterol and proteins. As a result, the liver may stop working as it should. However, acetylcysteine not only promotes the binding effect of glutathion, but also binds to Napqi itself.
Not every patient is a candidate for acetylcysteine therapy. In fact, some asthmatics are sensitive to the drug and experience further bronchoconstriction. In addition, large or long -term doses are known to reduce oxygen transport and increase blood pressure in the heart and lungs. This effect was particularly familiar with those who use dietary supplements in bodybuilding that often contain acetylcysteine.
other side effects of acetylcysteine include nausea, convulsions, drowsiness and inexplicable fever. Although there is no clear evidence that the use of this drug may disrupt fertility or cause congenitalDefects in humans, should be cautious if the patient is or can conceive. Nursing should also be carefully considered for nursing mothers, because it is not known whether this medicine passes into breast milk.