What Is a K Cell?

K cells account for 3% -15% of the total number of peripheral lymphocytes. K cells account for 2.5% -3.5% of peripheral blood. Above normal value or below normal value will cause adverse reactions to the body

Antibody-dependent cell (K cell) toxicity

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K cell (Killer Cell) is a type of lymphocyte that is neither T nor B. It has no surface Ig, but has Fc receptors, which can play a role in killing target cells with the participation of specific antibodies. When the target cell surface antigen is bound to the corresponding antibody, the Fc segment of the antibody binds to the surface of the K cell, forming an antibody bridge to contact the target cell to cause a killing effect. Therefore, the K cell is also called an antibody-dependent cell -mediated Cytotoxic (ADCC). This killing effect is non-specific and does not require complement participation.

Name

Antibody-dependent cell (K cell) toxicity

category

Immunology

K cells account for 3% -15% of the total number of peripheral lymphocytes. K cells account for 2.5% -3.5% of peripheral blood. Above normal value or below normal value will cause adverse reactions to the body

Abnormal results: The killing effect of K cells plays an important role in tumor immunity, antiviral immunity, antiparasite immunity, transplant rejection and some autoimmune diseases. The immune response produced is of two types: immune protection and immune pathology. If the target cells are too large (parasites or solid tumors), the phagocytes cannot function or the surface of the target cells is covered with antibodies, and the T cells cannot function when the T cells are not accessible. Rejection in kidney transplantation and destruction of the affected organs or tissues of the body's autoimmune diseases may be related to K cells. People to be tested: patients with organ transplant, patients with leukemia, cancer and primary immunodeficiency

Unsuitable people: no contraindications before testing: taking drugs that affect K cell toxicity requirements: testing the body's K cell activity as an indicator of immune function.

Inspection method: The method for detecting antibody-dependent cytotoxicity (ADCC) does not require labeling and can be performed on adherent cells in real time. The method includes, for example, (a) monitoring the impedance between electrodes on a non-conductive substrate supporting growth of target cells in the detection medium; and (b) one of adding effector cells and binding target cells to the detection medium Antibodies; after adding effector cells and antibodies, the impedance drop between the electrodes on the matrix indicates that ADCC function has taken effect in the test medium.

Antibodies, juvenile myelo-monocytic leukemia, intravascular large B-cell lymphoma, subcutaneous T-cell lymphoma

Cell enzyme activity is abnormal, hematocrit is high, cancer cells spread retrograde, eosinophils increase, and cell infection increases

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