What is the capillary escape syndrome?
Capillary leak syndrome, also called System Capillary Syndrome (SCLS) or Clarkson syndrome, is an extremely rare disorder that causes pores in the capillary leakage of excessive amount of plasma to the rest of the body. The leak causes a dangerous drop in blood pressure and swelling in the rest of the body, especially in the limbs. If it is not treated rapidly on the intensive care unit, the disorder may lead to multiple organ failure, limb loss and death. In the treatment of capillary escape syndrome, it may be in remission for years, although there is currently no cure. In a person with a capillary escape syndrome, pores open in these capillaries and leave a massive amount of leakage in plasma. The reason is not known, even if the acquired autoimmune failure has been designed and the possible cause. It is not considered inherited, and although doctors can test patients for monoclonal proteins in the urine as they try to diagnose Clarkson's syndrome, scientists do not think that they cause capillary escape episodes.
Episode of capillary leakage may be chronic, occurs almost a week or can be acute. Early symptoms resemble the head of colds with cold, overload and cough, but without fever or rash. As the episode proceeds, the patient develops low blood pressure, leading to a sense of weakness and nausea. Meanwhile, plasma escapes unpleasant swelling, especially in the limbs. Patients often faint due to low blood pressure and need to rush to the hospital and filled with liquids to keep them alive.
The diagnosis of capillary leak syndrome is easily omitted because it is first similar to the virus and then mimics polycythemia vara, another blood condition or sepsis from bacterial infection. Treatment is also difficult and must be carefully controlled to prevent complications. The patient should be admitted to an intensive care unit and administer enough fluids to increase blood pressure but not enough to increase the risk of swelling damagem. The patient also receives corticosteroid injections to slow down or stop plasma leakage, but this treatment is not always effective.
swelling associated with capillary leak syndrome may have a devastating effect, sometimes causing limb loss or organ failure, and doctors may need to surgery to prevent this damage. After the episode has passed, swelling continues to be a problem, because plasma accumulates around the lungs and hearts. Doctors often give patients diuretics to support urination for several days after the episode to get excess fluids from the body.
Patient usually recovers within a few days, although episodes are likely to repeat. Asthma drugs can help manage the recurrence of capillary leak syndrome, and steroids are often prescribed so that patients can start treating at the first episode symptoms. Even with this first defense line, Clarkson's syndrome may be deadly, so the patient should be admitted to the hospital for full treatment.