What Is Carnitine Deficiency?
Carnitine deficiency is a metabolic disease. The carnitine concentration in the patient's plasma and tissue is less than the level required for normal function.
Carnitine deficiency
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- Carnitine deficiency is a metabolic disease. The carnitine concentration in the patient's plasma and tissue is less than the level required for normal function.
- Biological effects of low carnitine levels are only clinically significant if they reach less than 10% to 20% of normal. L-carnitine deficiency may be direct or indirect. L-Carnitine is a naturally occurring hydrophilic amino acid derivative produced in the kidneys and liver and derived from the diet of meat and dairy products. It plays a vital role in transferring long-chain fatty acids into mitochondria for -oxidation. Carnitine can bind acyl residues and help its elimination in the body, thereby reducing the number of acyl residues bound to coenzyme A (CoA) and increasing the ratio of free state and acylated coenzyme A. [1]