What Is Chronic Rejection?

Chronic rejection usually occurs within months or years after surgery, and can also occur after acute rejection. Progress is slow, often insidious, and graft function gradually decreases or loses.

Chronic rejection

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Chronic rejection usually occurs within months or years after surgery, and can also occur after acute rejection. Progress is slow, often insidious, and graft function gradually decreases or loses.

Chronic rejection is dominated by humoral immunity, which is caused by low-level immune response of specific antibodies in the circulation, leading to perivascular inflammation, which causes the graft's vascular endothelium to continue to be damaged to a low degree, with vascular smooth muscle cell proliferation blocking the blood vessel, and the graft function gradually decreases .