What is Fanconi syndrome?

Fanconi syndrome is an unusual kidney disorder that affects the way the kidneys are processed by minerals and nutrients. The proximal tubules in the kidneys usually facilitate nutrient absorption into the bloodstream, including amino acids, phosphates, glucose and potassium. In the case of Fanconi syndrome, such compounds are not sufficiently metabolized and instead are excluded from the body of the urine. Several different symptoms and health problems such as fatigue, dehydration and bone thinning may develop. Most patients respond well to treatment in the form of carefully planned diet and everyday use of drugs, although some people have to receive kidney transplantation to avoid complications threatening life.

There are many potential causes of Fanconi syndrome. When a disorder affects infants and small children, this is usually due to inherited genetic abnormality. People of any age can get this disease if they have a basic cancer or blood disorder that the Affroduction of EC's blood proteinsT, such as multiple myeloma or amyloidosis. Some chemotherapeutic drugs and HIV drugs also correlated with the onset of kidney damage and fanconi syndrome. In addition, heavy metal poisoning can lead to kidney dysfunction in some patients if they are not immediately treated.

Symptoms of Fanconi syndrome in infants often include the inability to prosper, irritability, chronic fatigue and poor appetite. Lack of phosphates and other minerals necessary for bone growth can cause leg and arms deformities, weakness and small or no muscle tone. Adults who acquire this disease are highly prone to fractures of stress because their bones are thin and fragile. Excessive urination is a key finding in all age groups and can lead to other physical symptoms related to dehydration.

doctors diagnose Fanconi's careful review of the history of patients and perform a number of tests. Blood and urine samples are evaluated in hospital laboratories to check unusual levels of phosphates, calcium and other minerals. Screening toxicity are useful in confirming or excluding heavy metal poisoning as a potential cause. Ultrasound is also often taken to determine whether the renal tubules are deformed, blocked or injured.

treatment decision is taken on the basis of the severity of symptoms and basic causes. Patients may have to be hospitalized to receive intravenous fluids and drugs if they show signs of dehydration or heavy metal poisoning. Medicines are available to increase bone strength and strengthen the supply of nutrients lost in the urine. Doctors can also design some nutritional supplements, food and exercise that promote bone and muscle health in children and adult patients. If the condition does not improve despite medical care, patients can be placed on dialysis machines and planned to the kidneypantation.