What is Gilbert's Syndrome?
Gilbert syndrome is also known as constitutional liver dysfunction and hereditary non-hemolytic hyperbilirubinemia. It is more common in men and can occur at any age, but it is more common in 15 to 20 years old. The patient has no obvious symptoms and is generally in good condition. Clinically, it is characterized by chronic or recurrent jaundice, which can be stable or fluctuating. Emotional excitement, fatigue, cold, drinking, and concurrent infections can make jaundice worse. Jaundice worsens with weakness, indigestion, or mild pain in the liver. May have family history.
Basic Information
- English name
- Gilbert syndrome
- Visiting department
- Internal medicine
- Multiple groups
- More common in men
- Common locations
- liver
- Common causes
- Hepatocytes take up bilirubin and bilirubin and impair delivery to microsomes, or insufficient glucuronyltransferase activity in liver cells
- Common symptoms
- Jaundice, fatigue, indigestion, or mild pain in the liver
Causes of Gilbert syndrome
- Mainly due to liver cells uptake of bilirubin and bilirubin transport obstacles to microsomes, or inadequate glucuronyltransferase activity in liver cells, so indirect bilirubin in the blood increased.
Clinical manifestations of Gilbert syndrome
- This disease is more common in men and can occur at any age, but it is more common in 15 to 20 years of age. The patient has no obvious symptoms and is generally in good condition. Clinically, it is characterized by chronic or recurrent jaundice, which can be stable or fluctuating. Emotional excitement, fatigue, cold, drinking, and concurrent infections can make jaundice worse. Jaundice worsens with weakness, indigestion, or mild pain in the liver.
Gilbert syndrome test
- Liver function tests have normal or mildly elevated ALT, increased serum total bilirubin, mainly non-conjugated bilirubin, and a low-calorie card (400 kcal / day) test. After 24 hours, the blood unbound bilirubin exceeds the original level Times; Lumina test was positive. The red blood cell fragility test was normal, and the reticulocyte was not high.
- Imaging examination: The gallbladder showed good imaging.
Gilbert syndrome diagnosis
- Diagnosis can be made based on the above symptoms, signs, and laboratory tests.
Differential diagnosis of Gilbert syndrome
- Note the difference between hemolytic jaundice, obstructive jaundice, and viral hepatitis.
Gilbert syndrome complications
- May be complicated by bilirubin encephalopathy, neonatal hepatitis, viral hepatitis and so on.
Gilbert syndrome treatment
- The disease generally does not require special treatment and has a good prognosis.
Gilbert syndrome prevention
- Various incentives should be avoided. When jaundice occurs, liver enzyme inducers such as phenobarbital 3 times a day can be taken orally to increase the activity of glucuronyltransferase in liver cells and reduce indirect bilirubin in the blood.