What is immune reconstruction of inflammatory syndrome?
immune reconstruction of inflammatory syndrome (IRIS) is a complication of HIV, in which the improving immune system of the patient causes mass inflammation in response to already present opportunistic infection. Iris occurs when the HIV patient with a compromised immune system begins to respond to antiretroviral drugs. Symptoms arise quickly and may be fatal if infections include the brain. The treatment of the iris involves re -treatment of the basic condition that caused infection.
HIV affects the immune system and kills specialized white blood cells known as T-cells to replicate. Simple infections, such as colds, are no longer able to fight the body, and most HIV patients succumb to other infections than HIV. Drugs known as antiretrovirols slow down the HIV replication process. These drugs can have great success, hold the virus back and increase T-cell levels almost normal. This is when the levels of viruses decrease and T-cell levels rise immune to inflammatory reconstruction syndrome.
overBy starting antiretroviral treatment, the patient may have already concluded a viral infection. Because the body cannot cause an immune response, the patient may not have symptoms. In other cases, the patient had previously treated infection that still persists in the body. When the patient begins with antiretrovira treatment, the improvement of the immune system begins to attack for opportunistic infection.
Inflammation is a natural reaction of the body to infection. Symptoms of inflammatory immune reconstruction syndrome are generally located. Fever and pain, symptoms normal, when a healthy person captures infection, is very intensified when the HIV patient experiences Iris. The condition is potentially fatal, especially if inflammation is in the brain. More likely, however, the patient experiences some talcination of the problem if inflammation occurs.
Treatment of inflammatory immune reconstruction syndrome requires treatment of opportunistic infection. Antibiotics and other treatment may be required to stay inthe hospital. The course of corticosteroids helps most patients to reduce their inflammation. Restoration from any disease is complicated when the patient has HIV; Doctors monitor the patient's recovery more closely. An individualized treatment plan is always necessary.
If the patient recovers from immune reconstruction of inflammatory syndrome, antiretroviral therapy may continue. The prognosis is generally good if the patient continues his therapy after all dosing instructions. Any disease that the patient catches after recovery causes normal symptoms and not an extreme inflammatory reaction. If IRIS causes tissue damage, further medical treatment may be required.