What is Kallmann's syndrome?
Kallmann's syndrome is a rare state related to sex that occurs in less than 0.025% of the population. Its occurrence is more common in men than in women. It is an x-bound feature and affects the adrenal glands that cause lack of important endocrine hormones that are needed to make proper sexual development. Although at first it is difficult to detect, if the condition is left not treated, the absence or insufficient development of secondary sexual organs may occur and may also be the result of infertility.
It is difficult to determine whether a person suffers from Kallmann's syndrome mainly because the symptoms are not obvious until the patient is old enough to achieve puberty. Mechanisms that are the basis of the onset of puberty are still studying, so the effects of hormones in relation to puberty are not fully understood. When Kallmann's syndrome is suspected, blood sample analysis is required for proper diagnosis.
Sex hormones are one type of steroid hormoney signals from the hypothalamus in the brain. During puberty, the hypothalamus releases the gonadotropin (GNRH) hormone, which then releases gonadotropin into the bloodstream. The release of this hormone begins with a cascade of an event that helps start the process of puberty. The release of gonadotropin will act as a signal to the adrenal gland to release sexual hormones estrogen and testosterone that help the onset of puberty.
in people suffering from Kallmann's syndrome, a non -functional non -functional dysfunctional kidney due to reduced GNRH levels. Low Gnrh levels mean that lower gonadotropin levels are released. This in turn causes small or no release of sex hormones into the bloodstream.
The main problem caused by Kallmann's syndrome is the delayed onset of puberty and the development of secondary sexual characteristics. This may be offset if the patient receives regular sex hormone injections to act against reducedthe level of sex hormone. When men are treated with testosterone and women are treated with estrogen, this allows the development of normal secondary sexual characteristics.
Some patients with Kallmann syndrome have fertility problems. This can be fought with another form of hormonal therapy that makes the patient temporarily fruitful. Another common state associated with this syndrome is the inability to distinguish between different types of odors, a state known as anosmia.