What Is Liver Regeneration?
After most hepatectomy (PH) or liver injury, the number of hepatocytes decreased sharply, various feedback signals stimulated the proliferation of hepatocytes in the G0 phase, and the residual liver cells changed from a substantially non-growth state to a rapid growth through cell proliferation State to compensate for lost and damaged liver tissue and restore the physiological functions of the liver. This process is called liver regeneration (LR). At the same time, the body can accurately sense the size of the regenerating liver and stop liver regeneration in a timely manner.
Liver regeneration
- This entry lacks an overview map . Supplementing related content makes the entry more complete and can be upgraded quickly. Come on!
- Chinese name
- Liver regeneration
- Regulatory mechanism
- Liver regeneration
- Device officer
- liver
- Principle
- Hepatocytes proliferate
- After most hepatectomy (PH) or liver injury, the number of hepatocytes decreased sharply, various feedback signals stimulated the proliferation of hepatocytes in the G0 phase, and the residual liver cells changed from a substantially non-growth state to a rapid growth through cell proliferation State to compensate for lost and damaged liver tissue and restore the physiological functions of the liver. This process is called liver regeneration (LR). At the same time, the body can accurately sense the size of the regenerating liver and stop liver regeneration in a timely manner.
- Regulatory mechanism
- Liver regeneration includes regeneration of liver parenchymal cells and reconstruction of liver tissue structure. Hepatocytes play an important role in regeneration. A variety of cytokines and growth factors are regulated in the body by different mechanisms. TNF (tumor necrosis factor-a) and IL 6 (interleukin-6) can activate G0 phase liver cells and enter the cell cycle under the action of growth factors HGF (hepatocyte growth factor) and TGF (transforming growth factor-) Cyclin-dependent kinases (cyclin CDKs) system promotes liver [1] cells to enter S phase proliferation, and apoptosis and TGF are involved in stopping regeneration regulation. The research on the regulation mechanism of liver regeneration not only enriches the understanding and understanding of liver injury and postoperative regeneration and repair mechanism, but also opens up new prospects for organ transplantation.