What is the disease minimal change?

Minimal changes are the condition of the kidneys, which usually lead to nephrotic syndrome, especially in children. It leaves its name from the fact that the failure can only be detected under an electron microscope, because its appearance is too mild change of the cellular structure, which needs to be seen under a conventional microscope. Nephrotic syndrome is the name for a group of several symptoms, such as high cholesterol levels, low blood protein, high levels of triglycerides and excessive protein in the urine. It develops when nephronic blood vessels are damaged in nephron called glomeruli. There are several suspicious causes of minimal changes, including viral infection, allergic reactions or poor reactions to recent immunization.

Although the disease minimal changes do not have physically apparent symptoms, there may be some visible symptoms of nephrotic syndrome. The case may have urine, which looks foam, little appetite and detention of fluids experience weight. Can also swellingCha, legs, ankles and eyes.

In addition to swelling, it may be difficult to recognize the nephrotic symptoms caused by minimal changes in physical examination. Urine and blood tests often help to detect some of the indications of an earlier state, such as a large amount of protein in the patient's urine, high cholesterol or low levels of albumin in the blood. Some doctors may also perform kidney biopsy to obtain tissue for an electron microscope; This is usually the best way to diagnose minimal changes.

The most common way of treating the disease with minimal change is the administration of corticosteroid drugs. Depending on how the patient reacts to treatment, drugs can be used for the shortage of the shortage as a month or is adequately administered to prevent the state from returning. Corticosteriiods are the most effect in children, although adults also use drugs. If the disease continues to return, mNoho doctors will begin with a patient for cytotoxic therapy, where drugs such as cyclophosphamide, chlorambucil and cyclosporin may be administered.

Many doctors will also treat swelling associated with the disease. This may include administration of water pills, also known as diuretics and angiotensin converting enzyme (ACE) inhibitors. Patients may also undergo a blood pressure control program and reducing salt intake.