What Is Muckle Wells Syndrome?

Chronic Inflammatory Nerve, Skin, and Joint Syndrome (CINCA) (also known as the neonatal onset multi-system disease in North America, NOMID) is a rare inherited recurrent fever syndrome. The most common symptom is a rash at birth or within a week after birth. The name CINCA refers to the disease that appears in infancy and has the clinical manifestations of chronic meningitis. Joint involvement is one of the most important symptoms. CINCA is a lifelong disease and cannot be cured. Two other diseases are related to this disease because the genetic cause is on the same gene. These two diseases are more commonly found after infancy, and they are Muckle-Wells syndrome (MWS) and familial cold urticaria (FCU).