What is nephrogenic systemic fibrosis?
nephrogenic systemic fibrosis is a very rare connective tissue disorder that affects some people with acute or chronic kidney disease. The exact causes are not well known, but it seems that there is a causal link between the exposure of the Gadolinium element and the onset of symptoms. People who have a disorder usually develop stains of hard, tight, colored skin and joint pain and muscle weakness after dialysis treatment for their kidneys. Nephrogenic systemic fibrosis can be weakening because the skin and joints are very stiff. There are no reliable conditions for condition, but ultraviolet light therapies and topical creams can alleviate symptoms in some patients.
Gadolinium is commonly used as a monitoring dye for diagnostic imaging scanning. Fluorescent contrasting agents based on Gadolinia (GBCA) are used in many different types of magnetic resonance scanning, including angiography to help radiologists to monitor blood vessels and organs. Doctors are not ÚPLNNA sure how GBCA affects nephrogenic systemic fibrosis, but correlation is very well documented. The most likely explanation is that Gadolinium stimulates the activity of latent, immature connective tissue cells called fibrocytes. When fibrocytes become active, they enter the bloodstream and cause unfavorable reactions in connective tissue throughout the body.
A person who has a nephrogenic systemic fibrosis can experience a number of symptoms. Skrosis of the skin on the abdomen, chest, back or limbs can gradually harden and thicken over time. Repairs tend to be dark red and cause constant itching and burning. Since deeper connective tissue is influenced, the main joints can solidify, swollen and very painful. Some people have problems with bending and straightening hips, knees, elbows and fingers.
muscle weakness combined with joining can also make it impossiblewalk. Many people are limited to bed or wheelchairs, as their symptoms gradually deteriorate. If fibrosis spread to the kidneys, liver, heart or other main organ systems in the body, potentially fatal complications may occur.
Specialist can diagnose nephrogenic systemic fibrosis by evaluating physical symptoms and reviewing patients with dialysis procedures and imaging tests. Skin biopsy can be taken from a stain of the affected skin to confirm the diagnosis. Since the condition cannot be reversed, efforts for treatment are mainly focused on alleviating symptoms. There are several clinical evidence supporting the benefits of light therapy in softening the skin and healing of hard spots, but the actual efficacy of these procedures has not been verified. Most patients receive local creams to relieve itching and continue to receive the treatment of their kidneys in the hope of eventually solving the symptoms.