What is phosphatidylethanolamine?

phosphatidylethanolamine (PE) is an important phospholipid that forms cellular membranes and organelle membranes. It is also called cephaline because it is abundant in the brain, spinal cord and other nerve tissues. Up to 45% of brain phospholipids consist of cephalin. Cephalin plays an important role in knowledge and memory. In bacteria, phosphatidylethanolamine is the main phospholipid; In animals, lecithin or phosphatidylcholin is the most abundant, but cephaline is just a second. While phosphatidylcholine has choline connected to a phosphate group, PE has ethanolamine. PE fatty acids may be identical or different, but usually occupy 1.2 carbon positions. Sometimes, however, they can occupy 1.3 carbon positions. The body then takes the sophyphatidylethanolamine through a number of enzymatic steps. First, ethanolamine is phosphorylated by cytosolic enzyme called ethanolamine kinase. Second, the product of the first reaction is combined with triposphate cytidine to form cytidin ethanolaminfotransferase. Finally, an enzyme -bound to endoplasmic membraneana Reticula called Cytidine diffospo-ethanolamine: Diacylglycerol ethanolaminfotransferase affects the product of the second reaction and diacylglycerol to form PE.

The melting temperature of phosphatidylcholine is –20 degrees Celsius, while phosphatidylethanolamine is –16 degrees Celsius. PE has a higher melting point, so there is less liquid. It is assumed that phosphatidylethanolamine lends the lipid double -layer pressure, so that the membrane proteins achieve their stable confirmation. It is also assumed that it promotes the location of positively wondered amino acids on the inside of the membrane.

phosphatidylethanolamine has many other biological roles. It helps to stabilize sarcolmal membranes of heart tissues if there is insufficient oxygen intake, such as what is happening in coronary heart diseases. PE also plays a role in liver lipoprotein secretion with very low density as well as in membrane cleavage and fusioni. It passes through reactions to the donation of its ethanolamine component for the production of membrane protein chamber compounds called glycosylphosphatidylinositol. PE can also be converted into phosphatidylcholine phosphatidyl ethanolamine methyltransferase, enzyme present in the liver.

Cefalin is assumed that it plays a major role in maintaining the nervous system of intact and healthy due to its amount of functions and significant contribution to nerve tissues. Some supplements containing this phospholipid are available on the market. There is no solid foundation regarding the efficiency of supplements in maintaining and restoring the nervous system or in administration as a memory amplifier.