What Is Phosphatidylserine?

Phosphatidylserine is an important membrane phospholipid found in bacteria, yeast, plants, and mammalian cells. ^[1]

Molecular Structure

Phosphatidylserine (PS) ^[2]

Phosphatidylserine ^[4]

As a biologically active substance, phospholipids have unique physical and chemical properties and nutritional values. They have been widely used in food, health care, medicine and feed industries worldwide. People can use them to regulate blood lipids, improve memory, and protect them. The functions of the liver, brain, nourishment, and delay of aging and other physiological functions. Phosphatidylserine (PS) is a member of the phospholipid family. It is the only phospholipid that can regulate key protein functional states of cell membranes and is an indispensable substance in the human body. Therefore, as long as the normal intake of phosphatidylserine-based dietary agents does not cause additional burden on the body, and has passed the certification of the Drug Administration of many countries.

PS (phosphatidylserine) was approved by the Korea Food and Drug Administration (KFDA) in products supplemented with PS in May 2006, and promoted related products to "improve bad mood and enhance memory" to prevent dementia and other functions.

PS (phosphatidylserine) was approved by the US Food and Drug Administration (FDA) GRAS in October 2006, which means that PS (phosphatidylserine) can be used as a nutritional fortifier in yogurt, milk powder, bread, powder drinks and other food Add functional food ingredients.

PS (phosphatidylserine) was included in the list of foods (non-pharmaceuticals) by the Japanese Food and Drug HBM, and passed the individual review of food additives on February 5, 2010.

PS (phosphatidylserine) was added to the new resource food catalog by the former Ministry of Health of China (now renamed the National Health and Family Planning Commission) on October 21, 2010, allowing it to be used as a new resource food. ^[5]

Phosphatidylserine currently available on the market in China ^[6]

The researchers tested the memory-improving efficacy of fortified phosphatidylserine pure milk in a population test. (50% pure PS raw material is added into pure fresh milk at a ratio of 0.08%, and the ultra-high temperature sterilized milk process is made into PS milk) ^[9]

A large number of meta-analyses of PS have emerged in Europe and the United States (meta-analysis is a systematic quantitative or qualitative synthesis of the results of multiple independent studies on a problem), the main purpose of which is to objectively integrate the results of previous research Reflected. Cenacchietal. An analysis of 9 double-blind, placebo-controlled, 1224 patients participating in clinical trials, using cognitive and memory parameters as indicators. The results of this analysis show that parameters regarding cognition and memory after PS supplementation are significantly improved compared to placebo and starting values. There is no doubt that supplementing PS can improve long-term memory, long-term cognition, and the ability to talk freely and logically.

Earlier studies on PS were derived from bovine brain (bovine cerebral cortex PS). Later, considering safety issues, all studies on PS derived from bovine brain have been terminated since the first occurrence of BSE in the UK. In the mid-1990s, Degussa's Bioactive Substances Division (LucasMeyer) was determined to innovate and worked tirelessly to finally extract high-purity PS from soybeans, named Leci®-PS. Animal studies and clinical studies have confirmed that soy PS is as effective as bovine-derived PS. In 1998, Crook studied the effect of Leci®-PS on 50 people with an average age of 60.5 years. After three months, the memory and cognitive parameters were checked. It was found that the results were not only different from those of edible cow-derived PS (BC-PS), even Leci ®-PS results are better.

Phosphatidylserine ^[3] can reverse age-related memory deficits, especially in improving learning and remembering names. It can restore your ability to remember names to the level of 14 years ago, that is, Leci®-PS after 12 weeks, 66-year-olds have the memory of 52-year-olds.
Phosphatidylserine not only nourishes the brain of the elderly, but also relieves the physical and mental stress of healthy young people.
Some people have specifically tested the effect of PS in relieving mental stress. The trial used a double-blind, placebo control, giving healthy young college students 300 mg of phosphatidylserine daily for 30 days. College students must complete a difficult mathematical test within a given time, and record the stress response of these college students: including heart rate, college students' self-reported stress on the test. The students who used phosphatidylserine were better than the control group in terms of responsiveness, self-confidence, and performance. The test results also showed that the students in the phosphatidylserine group performed better.
In addition, other double-blind tests have also shown that phosphatidylserine can effectively reduce stress hormone secretion in young people under stress. Others have studied the effects of PS on healthy young people under physical and mental stress. The results show that PS can significantly relieve stress, greatly improve testers' performance, and improve visual analogue scale (visual analogue scale, VAS, used to evaluate individual systemic responsiveness). VAS refers to the subject's self-assessment of attention, alertness, and memory during the completion of prescribed movements and general motor ability test (GMAT). This function of PS is mainly due to its effect on the central nervous system (CNS), which improves alertness and attention, and makes it perform better.