What Is Primary Biliary Cirrhosis?

Primary biliary cirrhosis often coexists with other immune diseases such as rheumatoid arthritis, Sjögren's syndrome, scleroderma, and chronic lymphocytic thyroiditis. It is more common in middle-aged women, and it has an onset of insidious onset and has been slowly No significant decrease in appetite and weight, about 10% of patients may be asymptomatic. Attention should be distinguished from jaundice with secondary biliary cirrhosis and cirrhosis due to other causes. The disease is of unknown cause and chronic progressive cholestatic liver disease, which may be related to autoimmunity.

Basic Information

nickname

Hypertrophic or Cirrhotic Cirrhosis

English name

primary biliary cirrhosis

Visiting department

Gastroenterology

Multiple groups

Middle-aged women

Common causes

Unexplained may be related to autoimmunity,

Common symptoms

The skin and sclera were yellow stained, with multiple scratches and scaling. Enlarged liver and spleen with smooth surface and no tenderness

Clinical manifestations of primary biliary cirrhosis

Primary biliary cirrhosis often coexists with other immune diseases such as rheumatoid arthritis, Sjögren's syndrome, scleroderma, and chronic lymphocytic thyroiditis. It is more common in middle-aged women, and it has an onset of insidious onset and has been slowly Early symptoms are mild. Patients are generally in good condition. There is no significant decrease in appetite and weight. About 10% of patients have no symptoms. For patients with unexplained chronic progressive obstructive jaundice, especially those with fatty diarrhea, they should know the cause of the onset and the progress of the disease in detail, and whether other immune diseases are present. Pay attention to secondary biliary cirrhosis and Other causes of cirrhosis appear jaundice to identify. The patient's skin and sclera were yellow stained with multiple scratches and scaling. The liver and spleen were enlarged with smooth surface and no tenderness.

Examination of primary biliary cirrhosis

Laboratory inspection

Serum lipids, serum bile acid, combined with bilirubin, AKP, and GGT, and other microbiliary enzymes were significantly increased, and nitrogenase was normal or mildly and moderately elevated. Anti-mitochondrial antibodies were positive in the blood, IgM increased, and prothrombin time prolonged. Urinary bilirubin was positive, and urobilinogen was normal or decreased.

2. Imaging

Ultrasound, ERCP, CT, PTC, etc. to understand whether there is bile duct dilatation inside and outside the liver and diseases that cause extrahepatic obstructive jaundice.

Treatment of primary biliary cirrhosis

Take appropriate rest and give a high protein, high carbohydrate, high vitamin, low fat diet, daily fat <40-50g is appropriate. Supplement fat-soluble vitamins A, D, E, and K. Taking ursodeoxycholic acid for more than 6 months can improve clinical symptoms and laboratory test indicators; corticosteroids such as prednisone orally. Pay attention to the exacerbation of bone disease and bacterial infection in advanced patients. Both azathioprine and cyclosporine A are effective, but they should be used with caution due to renal toxicity and bone marrow suppression. When implementing treatment for disease processes, attention should be paid to side effects of the drug. Patients with liver decompensation and / or poor quality of life may be considered for liver transplantation.

Prevention of Primary Biliary Cirrhosis

Patients with typical clinical manifestations have no difficulty in diagnosis, but at this time, the disease is mostly advanced, so early diagnosis is the key to determining the success or failure of treatment. The following lifestyles help prevent this disease:

1. Absolutely no alcohol (including beer and rice wine), drink less beverages, drink hot tea.

2. Keep your diet constant every day. It is better to have low salt, low fat, less sugar, and high protein. Do not eat spicy, greasy, fried, and sticky foods. Do not overeating, and pay attention to diet hygiene to prevent diarrhea.

3. Try not to eat foods that damage the liver.

4. Maintain exercise habits and a good attitude.