What Is Quantitative Genetics?

Population genetics is a discipline that studies the genetic structure of a population and its changing laws. It studies the distribution of genes in a population, the maintenance and change of gene frequencies and genotype frequencies. The research object is the biological population, and the population here refers to the Mendelian population. It is a large, sexually propagating group consisting of the same species. Individuals within the population are mated randomly, following Mendelian genetic laws. Medical research on population heredity is to explore the frequency of hereditary diseases, hereditary methods, and their gene frequency and changes, so as to understand the laws of occurrence and spread of hereditary diseases in the population, and provide important information for the prevention, monitoring and treatment of hereditary diseases. And measures. (Li Yingbi) ^[1]

Population genetics

Population genetics is a discipline that studies the genetic structure of a population and its changing laws. It studies the distribution of genes in a population, the maintenance and change of gene frequencies and genotype frequencies. The research object is biological population, and the population here refers to Mendelian population. It is a large, sexually propagating group consisting of the same species. Individuals within the population are mated randomly, following Mendelian genetic laws. Medical research on population heredity is to explore the frequency of hereditary diseases, hereditary methods, and their gene frequency and changes, so as to understand the laws of occurrence and spread of hereditary diseases in the population, and provide important information for the prevention, monitoring and treatment of hereditary diseases. And measures. (Li Yingbi) ^[1]

Population genetics originated from British mathematicians

Group refers to

Research in genetics that governs a population of organisms (mainly a breeding population),

Study group

If all genes are linked, the role of one allele at one locus can be in the gene pool at other loci. In fact, one allele often appears at other sites of linkage disequilibrium genes, especially related to genes near the same chromosome. Recombination breaks this linkage imbalance too slowly to avoid genetic hitch when the allele of one locus rises to high frequency, because it selects an allele by linking to a nearby locus. Connections also slow down adaptation rates, even among the sexual population. The effect of association imbalance on slowing the rate of adaptive evolution is due to the Hill-Robertson effect (delay causes beneficial mutations together) background selection (delay separating beneficial mutations into harmful free-riders)

Linkage is a problem in population genetic models that deals with one genetic locus at a time. However, it can be used as a method to detect its behavior. Naturally selected through-hole selective scanning ...

In extreme cases, asexual population associations are complete, and population genetic equations can be derived and solved from travel. Wave genotype frequency along simple fitness landscape ... most microbes such as bacteria are asexually reproduced. Their population genetic adaptation has two contrasting mechanisms. When the beneficial mutation rate and population size are small, the asexual population follows the "succession mechanism" of origin-fixation dynamics, and the adaptation rate strongly depends on the product. When the product becomes larger, the asexual breeder follows a "concurrent mutation" mechanism, and the lower adaptation rate depends on the product, which is characterized by a new beneficial mutation appearing before the last interference of cloning ...