What Is Rapidly Progressive Glomerulonephritis?
Rapid progressive glomerulonephritis, also known as crescentic glomerulonephritis or extra-capillary proliferative glomerulonephritis, often dies from renal failure within weeks to months.
Rapid progressive glomerulonephritis
- Chinese name
- Rapid progressive glomerulonephritis
- Foreign name
- rapid progress glomerulonephritis, RPGN
- Also known as
- Crescentic glomerulonephritis
- which performed
- Rapid progressive glomerulonephritis, also known as crescentic glomerulonephritis or extra-capillary proliferative glomerulonephritis, often results in death from renal failure within weeks to months.
- Also known as crescentic glomerulonephritis or extra-capillary proliferative glomerulonephritis, the condition develops rapidly.
1 Rapid progressive glomerulonephritis 1) gross view
- The kidneys are swollen, pale, and there is a bit of bleeding on the surface of the cortex.
2 Rapid progressive glomerulonephritis 2) Microscopically
- Nephrosis, hyperplasia, or various other changes can occur in the glomeruli. The characteristic lesion is the formation of a large number of crescents in most glomeruli. Crescent bodies are mainly composed of proliferating parietal epithelial cells and exuded monocytes, and may also have neutrophils and lymphocytes. The above components are distributed crescently or annularly in the balloon wall layer outside the capillary bulb. Damage to the glomerular basement membrane results in exudation of cellulose, so there is more cellulose between the crescent somatic cell components. Cellulose exudation is the main factor that stimulates crescent formation. Early crescents are mainly composed of cellular components and are cellular crescents. After that, the fibrous components gradually increased, forming fibrous-cell crescents, and eventually crescents became fibrotic and became fibrous crescents. Crescent body formation narrows the glomerular cavity, and compresses the capillary plexus, resulting in loss of glomerular function.
3 Rapid progressive glomerulonephritis 3) under electron microscope
- Some cases showed sediment, and almost all cases had defects and rupture of the glomerular basement membrane.
4 Rapid progressive glomerulonephritis 4) immunofluorescence
- Some cases may show linear fluorescence or discontinuous granular fluorescence.
Clinical and pathological relationship of rapid progressive glomerulonephritis
- The condition of rapid progressive glomerulonephritis develops rapidly and the prognosis is poor. Without timely treatment, the patient may quickly develop oliguria, anuria and azotemia, and die until uremia. The prognosis is related to the extent of the lesion and the number and proportion of crescent formations. The greater the number, the worse the prognosis.