What is the process of drug production?
The
process of making tablets of drugs includes several main steps, including mixing or granulation of materials, lubrication, pressing and film coating. Different drugs will require different tablet production processes because sometimes sufficient homogeneous mixing requires further steps. The tablets require the correct dosing of the active ingredient as well as correct mixing, which includes evenly distributed ingredients in suitable quantities. Mixing processes generally occur when the ingredients are powder and require the machines to mix at high speeds. If mixing techniques are not adequate, medication processes will be implemented in the tablet production process.
The two main forms of granulation are wet granulation and dry granulation. During the wet granulation process, powder components are combined with a liquid known as Binder. The binder can be organic or aqueous and should avoid an inactivating drug and should also be carefully measured to ensure the best consistency and strength of the granules. AfterMixing granules are subject to the process of sown to stretch excessive aggregates, followed by the drying process.
Dry granulation is also often used in the process of making tablets and involves creating granules using compaction methods. It provides smaller granules than wet granulation, usually costs less and is usually used for materials that negatively respond to moisture. After one granulation process, the medicine is lubricated in a powder form of conventional fatty acids such as stearic acid.
As soon as the powder or granules are formed, the materials are compressed into a tablet form in a compact or pressing machine. This usually includes both pre -equalization and stage compression, which are performed at high speeds ranging from 50 to 500 milliseconds. Several factors may negatively affect the formation of tablets, including uneven weight distribution or powder density, stickiness and lack of lubricants and spinesAtnic machines that could potentially chip or damage newly created tablets.
tablets are also often covered in a mixture of polysaccharide for protection and improved taste. Not only do the coatings protect the drug and prolong their storage life, but also protect the esophagus and stomach lining from certain harder drugs, because tablets that take longer to dissolve the stomach irritation. Many tablets also contain grooves or markers that allow pills to be divided. Specialized machines are able to divide previously produced tablets to change the dosage in each pill.