Is it safe to combine trazodone and sertraline?

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combination of trazodone and sertraline is not safe due to the risk of serotonin syndrome, which is a potentially fatal condition resulting from the excessive stimulation of two receptors in the brain stem. Serotonin syndrome can result in many symptoms such as changed consciousness, hyperthermia and irritability. This condition is believed to occur due to similar trazodone and sertraline, which have a neurotransmitter serotonin. The same reaction may occur if the patient is taking the other two medicines that act on serotoni simultaneously.

Trazodone is an unusual antidepressant drug because it cannot be easily classified with other antidepressants. The drug has similar characteristics of both selective antidepressants reuptake of serotonin (SSRI) and tricyclic antidepressants such as trimaripamine. The drug works to increase the concentration of serotonin and norephinephrine in the brain and blocks the action of acetylcholine. Doctors believe that imbalance in these chemicals in the brain is one of the most commonthe causes of depression. By stimulating the production or serotonin and norephinephrine, the drug makes more of these chemicals available for the use of other nerves in the brain.

sertraline is classified as SSRI antidepressants. These work primarily on the levels of serotonin in the brain and make it more accessible to prevent nerves by preventing the nerves that originally released them in their re -takeover. This means that the total serotonin levels in the brain increase and serotonin is distributed between the nerves more even. Thus, trazodone and sertraline joined together, double the amount of serotonin in the brain, which could potentially throw the balance of neurotransmitters in the brain. This could lead to serotonin syndrome.

The greatest risk of a combination of trazodone and sertraline is serotonin syndrome, which may be fatal in some cases. Although the condition does not show up to be fatal, it is still veryserious condition. It is characterized by changes in mental state, gastrointestinal problems and some autonomous dysfunction. Serotonin syndrome occurs because some receptors in the brain are excessively stimulated. Some symptoms include changed consciousness, tremor and diarrhea, and many others may occur.

doctors sometimes advise patients to take trazodone and sertraline together if they believe that the potential benefits of treatment outweigh the risk. This decision should only be made by a healthcare professional and the patient should be carefully monitored for any symptoms that could indicate that it develops serotonin syndrome. Drugs should be stopped immediately if there are any symptoms and drugs blocking serotonin dry as chlorpromazine may be required to neutralize the condition.