What are inotrops?
Inotrops are substances used to change the energy of muscle contractions. These substances may be negatively inotropic or positively inotropic. Negative inotropic agents reduce the energy of muscle contractions and positively inotropic agents increase the energy of muscle contractions.
The most common inotrops association is the contraction of the heart muscle. More precisely, inotropic agents are usually medicines that are used to influence the strength of the heart muscle contraction. These muscle contractions can be increased or decreased by inotropic agents as needed. Inotropic activity may result from enlarged heart muscle in a state called chamber hypertrophy. Reduced inotropic activity can be caused by myocardial infarction or tissue of dead heart muscle tissue, which is more often known as a heart attack.
Inotrops, whether positive or negative, are set to help manage cardiac conditions. Most inotrops work based on the amount of calcium in the cytoplasm of muscle cell. This level is fromHill positive inotrops and decreases with negative inotrops. Not all drugs work based on the release of calcium and even among those who do it, the release mechanism may differ.
Negative inotropic agents are used to reduce myocardial contractility. This approach is used to release a tense or redesigned heart. Care is given because this treatment can lead to heart failure or deterioration. Negative inotropic agents include certain beta blockers who have been shown to reduce mortality and morbidity in congestive heart failure. Negative inotrops include beta blockers, calcium channel blockers, IA class antiarrrhythmics and IC antiarrhythmics.
On the contrary, to increase myocardial contractility, one would use a positive inotropic agent. This approach is used to treat several different heart conditions. Cardiomyopathy, decompensated citiesInviting heart failure, myocardial infarction, cardiogenic shock and septic shock are the disease most usually treated with positive inotropics.
positive inotropic agents are many and diverse. This group includes Berberin, derivatives of bipyridine, calcium, calcium sensitism and catecholamines. The group also includes eicosanoids, phosphodiesterase inhibitors, glucagon and heart glycosides such as digoxin. Digoxin, or digitalis, is an extract of Foxglove.
positive and negative inotrops can affect all types of muscles. They showed the greatest usefulness in the treatment of heart muscle conditions. The extreme importance of safe heart function means that inotrops are likely to continue to have the greatest impact on the treatment of heart conditions.