What Are L-Arginine Benefits?

L-Arginine is a chemical substance with a molecular formula of C6H14N4O2. After recrystallization from water, it loses crystal water at 105 , its water solubility is strongly alkaline, and it can absorb carbon dioxide from the air. Soluble in water (15%, 21 ° C), insoluble in ether, slightly soluble in ethanol.

L-Arginine

L-Arginine is a chemical substance with a molecular formula of C6H14N4O2. After recrystallization from water, it loses crystal water at 105 , its water solubility is strongly alkaline, and it can absorb carbon dioxide from the air. Soluble in water (15%, 21 ° C), insoluble in ether, slightly soluble in ethanol.

For adults

Chinese name: L-Arginine

Chinese synonyms: L-arginine; 2-amino-5-guanidinovaleric acid; L-protein amino acid; guanidylvaline; arginine; L-2-amino-guanidinovaleric acid; L-guanidino Valine; L-arginine base

English name: L (+)-Arginine

English synonyms: L (+)-ARGININE; L-ARGININE; L-ARGININE BASE; L-ARG; L-2-AMINO-5-GUANIDINOVALERIC ACID; ARG; ARGININE, L-; FEMA 3819

Molecular formula: C6H14N4O2

Molecular weight : 174.2

Related Categories : Amino Acids and Derivatives; pharmacetical; chiral; Arginine [Arg, R]; Amino Acids; Amino Acids and Derivatives; for Resolution of Acids; Optical Resolution; alpha-Amino Acids; Biochemistry; Synthetic Organic Chemistry; L-Amino Acids L-type amino acids; Amino Acids; food additives; food and feed additives;

Melting point	222 ° C (dec.) (Lit.)
Specific rotation	27.1 o (c = 8, 6N HCl)
Refractive index	27 ° (C = 8, 6mol / L HCl)
FEMA	3819
Storage conditions	Store at 0-5
Solubility	H2O: 100 mg / mL
form	powder
Water solubility	148.7 g / L (20 )
Sensitivity	Air Sensitive
Merck	14,780
BRN	1725413
stability	Stable. Incompatible with strong oxidizing agents.
CAS database	74-79-3 (CAS DataBase Reference)
NIST Chemical Substance Information	L-Arginine (74-79-3)
EPA Chemical Substance Information	L-Arginine (74-79-3)

Maximum Allowable Use Level of Food Additives	Chinese name of the additive The Chinese name of the food that is allowed to use the additive Function of the additive Maximum allowable amount (g / kg) Maximum allowable residual amount (g / kg) Exceeding the maximum allowable usage and maximum allowable residue in GB 2760
Chemical properties	White rhombus crystals (precipitated from water, containing 2 molecules of crystal water) or monoclinic flaky crystals (no crystal water), odorless, bitter taste; easily soluble in water (solubility in water at 83 ° C is 83g / L, solubility in water at 50 ° C 400g / L), very slightly soluble in ethanol, insoluble in ether; pI 10.76; loses two molecules of crystal water when heated to 105 , the color becomes darker at 230 , the decomposition point is 244 ; specific rotation [] 20D + 12.5 ° (0.5-2.0mg / ml, H2O), [] 20D + 27.3 ° (0.5-2.0mg / ml, 6mol / L HCl); the aqueous solution has the maximum absorption at 205nm (1g3.28).
use	For biochemical research, various types of liver coma and viral liver alanine aminotransferase abnormalities.
use	Nutritional supplements; flavourings. Heating with sugar (amino-carbonyl reaction) to obtain special flavor substances. GB 2760-2001 stipulates that food flavors are allowed. An important component of amino acid infusion and comprehensive amino acid preparations.
use	Amino acid drugs.
use	Used as pharmaceutical raw materials and food additives
use	Arginine is an essential amino acid to maintain the growth and development of infants and young children. It is an intermediate metabolite of the ornithine cycle, which can promote the conversion of ammonia to urea, thereby reducing blood ammonia content. It is also the main component of sperm protein, which promotes sperm production and provides sperm motility energy. In addition, intravenous arginine can stimulate the pituitary to release growth hormone, which can be used for pituitary function tests.
production method	Using gelatin or pig hair, pig blood meal, etc. as raw materials, after hydrolysis, the amino acid hydrochloride is extracted from the hydrolysate (see 03400), and then the finished product is obtained by removing hydrochloric acid.
production method	It is obtained by separating protein (such as gelatin) hydrolysate by ion exchange resin or barium hydroxide. It is usually made into the hydrochloride salt, but it is also stable in the free state, so there are also free products for sale. It can also be prepared by fermentation using saccharides as raw materials.
production method	Gelatin is used as a raw material, and phenylmethylene arginine is obtained by condensing with benzaldehyde after the hydrolysis of hydrochloric acid, and then the product is refined by hydrochloric acid hydrolysis, activated carbon treatment, and column chromatography.
category	Poisonous
Toxicity classification	Poisoning
Acute toxicity	Reference value: peritoneal cavity-rat LD50: 3793 mg / kg
Flammability hazard characteristics	Combustible; combustion produces toxic nitrogen oxides smoke
Storage and transportation characteristics	Treasury ventilation, low temperature and dry
Extinguishing agent	Dry powder, foam, sand, carbon dioxide, mist water
Professional standards	STEL 10 mg / m3

L-Arginine (L-1-Amino-4-guanidovaleric acid)

For adults

1. In the body, it is an intermediate metabolite of the ornithine cycle, which can promote the production and excretion of urea, correct ammonia poisoning and relieve liver coma. Arginine is also the main component of sperm protein, which has the effect of promoting sperm production and increasing sperm motility.

2. Exist in tobacco leaves.

3. Is an important part of sperm protein. Crystallization from water is a dihydrate, and the crystal water is lost at 105 & ordm; C. Crystalline Anhydrous from Ethanol

Extraction method

2. Tobacco: BU, 22; Synthesis: Hydrolyzed and refined from gelatin. Can also be synthesized by chemical methods

Nutritional supplements. Arginine is a component of the ornithine cycle and has extremely important physiological functions. Eating more arginine can increase the activity of arginase in the liver and help Ammonia is converted into urea and excreted. Therefore, arginine is important for hyperammonemia and liver dysfunction.

L-arginine is also the main component of sperm protein, which has the effect of promoting sperm quality and increasing sperm motility.

Arginine can effectively improve immunity, promote the immune system to secrete endogenous substances such as natural killer cells, phagocytic cells, and interleukin-1, which is conducive to fighting cancer cells and preventing viral infections. In addition, arginine is a precursor of ornithine (L-ornithine) and proline (L-proline). Proline is an important element constituting collagen. Supplementation of arginine is necessary for severe trauma and burns. A large number of tissue repairs have obvious help, and have the effect of reducing infection and inflammation.

Arginine has ameliorating effects on some renal diseases and partial dysuria caused by excessive renal pressure. However, since arginine is an amino acid, it may also cause a burden on patients with renal failure, so it is important for severe renal insufficiency. It is best to consult with the attending physician before using it.

L-Arginine

One

Primary concentration stage

Raw material: Mother (product of primary neutralization in cystine production).

Excipients: steam.

Pass mother I into the primary concentration tank and steam. The temperature is 120 ° C, the pressure is -0.09Mpa, and the concentration time is 6h. Crystallize and filter.

End product: crystallization solution (go to the decolorization stage).

two

One decoloring section

Excipients: activated carbon, pure water, resin.

The crystallization solution enters a decolorization tank, and activated carbon and pure water are put into it. The temperature was 80 ° C, and the decolorization time was 2h. After filtration, the filtrate was adsorbed by resin.

End products: 1. Filter residue (recycling); 2. Easy (go to the secondary concentration section).

three

Secondary concentration section

Excipients: steam, alcohol.

The filter residue enters the primary concentration tank and is steamed. The temperature is 120 ° C, the pressure is -0.09Mpa, the concentration time is 6h, and the crystal is soaked with alcohol.

End product: 1. Crystallization liquid (to the secondary concentration section).

four

Secondary bleaching section

Excipients: steam, pure water, activated carbon.

The filtrate enters the secondary decolorization tank, and steam (pure water) and activated carbon are passed in. The temperature was 80 ° C, the decolorization time was 2h, and the solution was filtered.

End products: 1. Filter residue (recycling); 2. Filtrate (go to the third concentration section).

Fives

Tertiary concentration stage

Excipients: steam, alcohol.

The filter residue was put into three concentration tanks, and steam was introduced. The temperature is 120 ° C and the pressure is -0.09Mpa. The concentration time is 6h. The crystals are soaked with alcohol and filtered.

End products: 1. Filtrate (recycling); 2. Crystals (ie crude L-arginine, de-refined).

six

Refined section

Excipients: distilled water

Rinse the product from the previous process with distilled water and centrifuge to dry, send it to the drying room, dry, pack, and store. The drying temperature is 100 , and the drying time is 6h.

End product: finished L-arginine. Cysteine hydrochloride monohydrate