What are the different types of progeria treatments?
Since there has been no cure for progeria since 2011, they tend to focus on preventing complications and alleviating symptoms. Common treatment, such as low dosage aspirin, physical therapy and tubes, are designed to facilitate symptoms of progeries rather than cure or prevent the condition. In clinical trials, potential drug treatment is studied, including inhibitors of farnesyltransferase (FTI), bisphosphonate called Zoledron and Pravastatin statin.
A typical treatment for this condition is aspirin with a low dose collected. Low -dose aspirin can prevent heart attacks and stroke, the two most common causes of children of children with this disorder. Aspirin works by reducing the clustering effect of blood inserts in the blood and preventing clotting from preventing blood into the heart and brain.
Physical and working therapies are also common progeria treatment. These therapies focus on the stiffness of the joint and problems with the movement of hip. The thecíc is to maintain the patient as long as possible.
Other progie treatments focus on maintaining the patient's weight and nutrition. An infant with a condition may have difficulty feeding and requires a feed tube and a syringe. Dietary supplements can also help prevent weight loss and ensure that the child receives the necessary nutrients every day.
In some children, it may be necessary to extract baby teeth. Permanent teeth can start to come before the primary fall out. This can lead to the second row of teeth or overfill if extraction is not done.
The French research team created the development of potential drug therapies for a possible condition when they discovered a gene mutation responsible for syndrome in 2003. Disabled children have a mutation in the LMNA gene, resulting in the production of abnormal prelamine and OR Prigerin. Clinical studies focus on drugs that are assumed to prevent progestin in cell damage and cause genetic instability that triggers the symptoms of progErie.
Ftis as Lonafarnib, Pravastatin and Zoledronic acid work by preventing the Molecule called Farnesyl group in the connection to Prigerin. When this molecule connects to progerin, the normal cell function and the results of the progie are inhibited. Each of the three drugs affects a different step in the cellular process that creates the Farnesyl group.
Lonafarnib was originally developed for the treatment of cancer, including brain tumors, and it works by inhibiting the enzyme needed to connect the farnesyl group to protein, such as Prigerin. Pravastatin statin is usually given to lower cholesterol, but also blocks the production of farnesl. Zoledronic acid is a bisphosphonate that increases bone density and prevents farnesl, as well as ortastatin.
It is assumed that the combination of these drugs can be multi -effective than the management of each individually. This potential progie treatment has been shown to restore the cores of the cells of cells to normal in cellular cultures. He is not yet knownMO, whether any of these drugs cure or prevent syndrome, but can allow patients to live longer and healthier lives.
Progeria is an extremely rare progressive genetic disorder that causes rapid aging in children. Since 1886 only approximately 130 cases have been documented. A child with a disorder often seems normal at birth, but symptoms such as hair loss and skin changes usually occur within 12 months. Suffering often die of cardiovascular disease or stroke, and the average life expectancy is 13, although some have been living for more than 20 years.