What are the risks of a combination of paracetamol and alcohol?

Paracetamol, known in the United States such as acetaminophen, is an analgesic and antipyreta drug commonly used to treat pain, headaches and fever. It is widely available at the counter, either by itself or as part of the cold and flu. Like many drugs, too much paracetamol can be very dangerous. In many countries, the sale of paracetamol is limited to be against the risk of paracetamol overdose overdose. The risk of paracetamol overdose is generally assumed that some combinations of paracetamol and alcohol are impaired, but medical evidence seems to support this claim. When the human body metabolizes paracetamol, it produces N-acetyl-P-Benzochinoneimin or Napqi, a toxin capable of destroying liver cells and exhausting the natural level of the liver glutathion, antioxidant. However, this toxin is usually produced only in small quantities. When inward individual overdose on paracetamol is produced more Napqi than they can detoxify the liver, resulting in abdominal painCha, nausea and eventually even death. If the toxicity of paracetamol is identified early, it can be treated, but if it is unnoticed, the risks are very large. In fact, the use of paracetamol does not increase the risk of toxicity in the recommended dose in drinking. Even the combination of alcohol with paracetamol overdose does not seem to increase the risk of serious damage, although the risk of toxicity of paracetamol from overdose remains serious.

Some doctors have proposed on the basis of tests performed on animals that paracetamol toxicity may be impaired by chronic excessive alcohol consumption. According to this theory of chronic alcohol abuse, a large amount of CYP2E1 enzyme produces that Helps production of paracetamol toxins. Despite the fact that this faith is widespread, evidence is ambiguous for it.

articles published in medical journals Critical care , ITISH Journal of Clinical Farmacology claimed that despite some evidence that long -term alcohol abuse increases the toxicity of paracetamol, there is no evidence of paracetamol and alcohol the risk of toxicity in humans. The liver damage observed in chronic alcohol rapists who passed the overdose with paracetamol was also observed in those who did not consume excessive alcohol. Thus, despite the widespread belief that paracetamol and alcohol have negative interactions, it seems that clinical evidence for the justification of this faith is missing.