What factors affect a sufficient dose of cisplatin?

Sufficient dose of cisplatin is affected by many factors such as patient size, treated condition, patient reaction to medicine and other medicines with which it is combined. A dose of cisplatin may be reduced if the patient has kidney problems. The recommended dose of cisplatin for bladder cancer is between 50 and 70 milligrams (mg) per meter second (m

2 ) in body size. This dose increases in larger patients or patients resistant to its effects. Doses for other conditions, such as cervical cancer, differ depending on which drug is used in combination.

The patient's size is the main factor in determining the correct dose of cisplatin. Most doses are given on the M ^{2 in the body size. For example, a patient taking a cure for testicular cancer requires 20 mg per size m}

2 . If the patient is in size 2 m ^{2 , it will require 40 mg. The patient size of 1.5 m 2 requires a dose of 30 mg.}

different IenTS for treatment can determine the right dose of cisplatin. The neuroblastoma dose is 60 to 100 mg per m ^{2 . Most cancer treatment is administered at the maximum possible dose without causing serious side effects in the patient. Two patients of the same size could have different doses if one reacts worse to the medicine. All doses must still fall to that extent to be effective and safe.}

specific cancer are often treated with different amounts of drugs. For example, the required dose of cisplatin for bladder cancer is 50 to 70 mg per m ^{2 . Pipes suffering from cells without cells require a dose between 60 and 100 mg per m 2 in the body size. Cancer of testicles requires a much smaller dosing of 20 mg per m 2 . Most doses for different cancer do not exceed 100 mg per m 2 in the body size.}

Combined therapies commonly uses in a pacCancer entits, which may affect the required dose of cisplatin. Patients with cervical cancer require radiation therapy medicine require a dose of 40 mg per m ^{2 . If the drug is combined with paclitaxel, the required dose of cisplatin increases to 75 mg per m}

2 . Other chemotherapeutic drugs combined with cisplatin can change the required dose to 50 mg per m ^{2 .}

Patients who have kidney problems must be reduced doses. The kidney function is measured by creatinine clearance of the patient. If the patient has creatinine clearance between 10 and 50 milliliters per minute (ml/min), 75 percent of the usual dose of cisplatin requires. Patients with creatinine clearance below 10 ml/min should have half of the normal dose.