What factors affect a sufficient dose of glyburide?
Glyburide is a drug sulfa used in the treatment of blood sugar levels in people suffering from diabetes mellitus type II. Although diet control and exercise is the most effective means of controlling this condition, Glyburide can supplement these approaches to the treatment of diabetes by helping to reduce blood sugar. This drug is sometimes used to reduce the severity of injury caused by brain swelling in patients with stroke. When calculating a suitable dose of gloyburide for originally, it is important to take into account the patient's age, kidney health and liver health, as well as in the form of a drug to be used. Patients have switched to gloyburide from another, long -acting drug to reduce blood sugar levels should be administered with reduced doses and be carefully monitored in terms of symptoms of hypoglycemia for the first week of use.
When administering this drug adult with diameter of type II, the initial dose of gloyburide should be 2.5 mg in the morning with breakfast. PThe use of a micronized mold should be only 1.5 mg. A maintenance dose between 1.25 and 20 mg of conventional gloyburide or 0.75 to 12 mg of micronized gliburide can be shown in one or two divided doses throughout the day. More than 20 mg of conventional or 12 mg micronized gliburide should not be used in the 24 -hour period. Initial dose in patients aged 65 years or older may be reduced to just half of the standard dose of gloyburide, although the standard dose may still be administered in serious cases. Increasing the dose of glaburide may be considered every seven days in the increments of 2.5 mg of conventional mold and 1.5 mg of micronized mold.
In patients suffering from reduced kidney function, dose settings may be necessary. The initial dose of gliburide should be half the standard dose of adults given once a day. The integration of the maintenance of the patient's treatment regime should be carried out with caution. Because medicines are not removed by dialysis, not required to replenishKing doses in patients undergoing this procedure. The same dose treatment recommendations should be followed when administering gloyburide patients with reduced liver function.
other risks of gliburide include some serious and potentially fatal drug interactions, especially with drugs Gatifloxacin and Bosentan. Alternative drugs should be used as gatifloxacin can cause hypoglycaemic coma, while bosentan can cause severe liver damage. In addition to the risk of hypoglycaemia during overdose, some patients also develop cholestatic jaundice, which is more commonly common in patients using gloyburide in combination with metformin antidiabetics.