What Factors Affect a Sufficient Metronidazole Dose?

Forbidden for food and feed processing

Metronidazole tablets, the indication is for the treatment of intestinal and parenteral amoebiasis (such as amoebic liver abscess, pleural amoebiasis, etc.). It can also be used for the treatment of vaginal trichomoniasis, pouchiasis and cutaneous leishmaniasis, and guinea worm infection. It is also widely used in the treatment of anaerobic infections.

Drug Name: Metronidazole tablets

Drug type: Prescription medicines, essential medicines, medicines for medical workers' injuries
Use classification: Synthetic antibacterials

Metronidazole Tablets Caution

Forbidden for food and feed processing

Metronidazole Tablets Ingredients

Ingredients: metronidazole.
Chemical name: 2-methyl-5-nitroimidazole-1-ethanol.
Chemical Structure:

Molecular formula: C ₆ H ₉ N ₃ O ₃
Molecular weight: 171.16

Metronidazole Tablet Properties

This product is white or off-white film.

Metronidazole tablets indications

For the treatment of intestinal and parenteral amebiasis (such as amoebic liver abscess, pleural amebiasis, etc.). It can also be used for the treatment of vaginal trichomoniasis, pouchiasis and cutaneous leishmaniasis, and guinea worm infection. It is also widely used in the treatment of anaerobic infections.

Metronidazole tablets specifications

0.2g.

Metronidazole tablets dosage

1. Common dosage for adults Intestinal amoebiasis, 0.4 0.6g (2-3 tablets) at a time, 3 times a day for 7 days; Extra-intestinal amoebiasis, 0.6-0.8g (3-4 Film), 3 times a day, 20 days of treatment.
Giardiasis, 0.4g (2 tablets) at a time, 3 times a day, 5 to 10 days.
Medicinal worm disease, 0.2 (1 tablet) g at a time, 3 times a day, 7 days of treatment.
Parsiculariasis, 0.2g (1 tablet) at a time, twice a day for 5 days.
Leishmaniasis of the skin, 0.2g (1 tablet) at a time, 4 times a day, 10 days of treatment. Repeat the course after 10 days.
Trichomonas, 0.2g (1 tablet) at a time, 4 times a day, 7 days of treatment; suppositories can be used at the same time, 0.5g per night into the vagina, for 7 to 10 days.
Anaerobic infection, oral 0.6-1.2g (3-6 tablets) daily, divided into 3 times, 7 to 10 days as a course of treatment.
2, commonly used in children amoebiasis, daily weight of 35 to 50mg / kg, divided into three oral administration, 10 days as a course of treatment.
Giardiasis: Take 15 to 25 mg / kg of body weight daily, orally three times a day for 10 days. The dose for treating guinea worm disease, sachet disease, and trichomoniasis is the same as Giardiasis.
Anaerobic infection, oral dose of 20-50mg / kg daily.

Metronidazole tablets adverse reactions

Adverse reactions occur in 15% to 30% of cases, and the most common gastrointestinal reactions include nausea, vomiting, loss of appetite, abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, occasional paresthesia, limb numbness, Ataxia, polyneuritis, etc., large doses can cause convulsions. A few cases of urticaria, flushing, pruritus, cystitis, dysuria, metal taste in the mouth, and decreased white blood cells are reversible, and they will recover on their own.

Metronidazole tablets contraindications

Patients with active central nervous system disorders and hematological disorders are prohibited.

Precautions for metronidazole tablets

(1) Interference to diagnosis: The metabolites of this product can make the urine appear dark red.
(2) The dose of patients with original liver disease should be reduced. The drug should be discontinued in the presence of ataxia or other central nervous system symptoms. Before repeating a course, a white blood cell count should be performed. In patients with anaerobic infection and renal failure, the interval between administration should be extended from 8 hours to 12 hours.
(3) This product can inhibit alcohol metabolism. You should stop drinking during medication. Abdominal pain, vomiting, headache and other symptoms may occur after drinking.

Metronidazole tablets for pregnant and lactating women

Banned for pregnant and lactating women.

Metronidazole tablets for children

Reference dosage

Metronidazole tablets for elderly

still uncertain.

Metronidazole tablets drug interactions

This product can enhance the effect of anticoagulant drugs such as warfarin. Combining it with oxytetracycline can interfere with the effect of metronidazole on clearing trichomoniasis.

Metronidazole tablets overdose

Large doses can cause convulsions.

Metronidazole tablets pharmacology and toxicology

This product is a nitroimidazole derivative, which can inhibit the redox reaction of amoeba and cause the nitrogen chain of the protozoa to break. In vitro tests have shown that when the drug concentration is 1 to 2 mg / L, morphological changes of amoeba histolytica can occur within 6 to 20 hours, and all of them can be killed within 24 hours. The concentration of 0.2 mg / L is within 72 hours. Kill amoeba. This product has a powerful killing effect on trichomoniasis, and its mechanism is unknown.
Metronidazole has a killing effect on anaerobic microorganisms, and the metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial DNA, thereby interfering with the growth and reproduction of bacteria, and eventually causing the death of bacteria.
Carcinogenic to some animals.

Metronidazole tablets pharmacokinetics

It can be quickly and completely absorbed after oral or rectal administration, protein binding rate [5%, widely distributed in various tissues and body fluids after absorption, and can pass the blood-brain barrier, and the effective concentration of the drug can appear in saliva, placenta, bile, milk , Amniotic fluid, semen, urine, pus and cerebrospinal fluid. It has been reported that the concentration of the drug in the placenta, milk, and bile is similar to the blood concentration. The plasma concentration of cerebrospinal fluid in healthy people was 43% of that in the same period. In a few patients with brain abscess, after taking 1.2 to 1.8 g daily, the drug concentration of pus (34 to 45 mg / L) is higher than the blood concentration of the same period (11 to 35 mg / L). After infection in the ear, the drug concentration in the pus was above 8.5 mg / L. The blood drug concentration reached a peak 1 to 2 hours after oral administration, and the effective concentration could be maintained for 12 hours. The plasma concentrations after oral administration of 0.25g, 0.4g, 0.5g, and 2g were 6, 9, 12, and 40 mg / L, respectively. 60 to 80% of this product is excreted through the kidney, about 20% of the original drug is excreted from the urine, and the rest is excreted in the form of metabolites (25% are glucuronic acid conjugates and 14% are other metabolic conjugates), 10% With feces, 14% are excreted from the skin.

Metronidazole tablets storage

Shaded and sealed.

Metronidazole Tablets Packaging

Oral solid medicinal high-density polyethylene bottles of 100 tablets per bottle; 21 bags of pharmaceutical packaging compound bags; 20 tablets of aluminum-plastic board per plate, 1 plate per box; 2 plates per box.