What factors affect a sufficient dose of metronidazole?

Metronidazole drug is a broad -spectrum antibiotic used in the treatment of a wide range of bacterial and protozoal infections. The appropriate dose varies considerably according to the condition of the treated and age of the patient, as well as its level of renal and liver function. Because this drug can develop serious side effects, including encephalopathy, peripheral and optical neuropathy, convulsions, aseptic meningitis, brain lesions and cancer, the lowest possible dose of metronidazole should be administered.

The wide range of health conditions is caused by amoebic infections, most of which can be treated with this drug. The standard dose of Metronidazole for Amebias for adults is administered orally between 500 and 750 mg, three times a day for five to ten days. Infants and young children should instead use 35 to 50 mg/kg in three divided oral doses every day.

trichomoniasis can also be steamed using a metronizadle. In adults, a dose of 500 mg may be used for one week. ANDOne dose of 2 g can be filed. The patient's sexual partner should also be tested and treated to prevent reinfection.

In the treatment of pseudomembranous colitis, a lower dose of metronidazole can be administered between 250 and 500 mg. Medicines should be taken three to four times a day. Treatment should continue for 10 to 14 days. Pediatric patients should receive 20 mg/kg daily in four doses every six hours. Pediatric patients should not be given more than 2 g per day.

In the treatment of either dracunculiasis or giardia, the dose of 250 mg metronidazole should be administered orally every eight hours. In dracuncliasis, the course of the Trjs lasts on average ten days. Giardiasis may require only seven days of treatment, although the treatment time may be prolonged if necessaryin serious cases.

In ulcerative conditions caused by Heliobacter pylori infections, metronizadol can be effective. An oral dose of 250 mg should be administered every six hours. The average length of therapy for effective treatment of this condition is 14 days.

Metronizadol is also occasionally used for surgical prophylaxis, such as contaminated intestinal surgery to prevent postoperative infection or sepsis. Before the surgery, a dose of metronizadol 15 mg/kg should be administered intravenously for 30 to 60 minutes, no later than an hour before the operation. The postoperative dose of 7.5 mg/kg in the same period of time should be administered after six and again 12 hours.

Lower doses should be used in older patients or patients with reduced liver function, which requires detailed monitoring of the drug level in blood circulation when starting treatment. Patients with severe renal insufficiency, which means they have CRCL levels less than 10 ml/min, should use half of the recommended dualMetronidazole. Because the drug is removed by dialysis, patients may not receive this treatment, they may not require a dose reduction.