What Factors Affect a Sufficient Vancomycin Dosage?

Vancomycin hydrochloride is a narrow-spectrum antibiotic, which is only effective against gram-positive bacteria, such as hemolytic streptococcus, pneumococcus, and enterococcus, etc., which are all sensitive, especially sensitive to drug-resistant Staphylococcus aureus. Its mechanism of action is to inhibit the synthesis of bacterial cell walls. It mainly binds to bacterial cell walls and prevents certain amino acids from entering the glycopeptides of the cell walls. Clinically, it is mainly used for severe infections caused by penicillin-resistant Staphylococcus aureus, such as pneumonia, endocarditis, and sepsis. It also has a good effect on infections and sepsis caused by hemolytic streptococcus.

Vancomycin hydrochloride

Vancomycin hydrochloride is

1.

1. Ototoxicity can appear tinnitus or ear fullness, hearing loss or even lack of hearing,

1. with

It is limited to intravenous administration only. For adults, it is 1 to 2 g / day, divided into 2 to 4 times. Children 20mg-40mg / kg daily, newborns 12.5mg-25mg / kg daily, divided into 2 to 4 times.

1 Sometimes can cause chills, rash, drug fever, and thrombophlebitis.

2 Long-term or heavy use can damage hearing and kidney function. Once hearing loss is impossible, tinnitus is a premonitory symptom, and medication should be discontinued if there is tinnitus.

3 Disabled in patients allergic to glycopeptide antibiotics. Pregnancy class C. Use with caution in pregnant and lactating women and patients with severe renal insufficiency. The pharmacokinetic characteristics of this product vary greatly from individual to individual, and blood concentration monitoring should be performed. Generally, peritoneal dialysis and hemodialysis have little effect on the excretion of this product, but hemodialysis with charcoal and resin can quickly clear this product. See Norvancomycin Hydrochloride.