What factors affect Reglan dosing?
Reglan®, also sold under its generic name Metoclopramide hydrochloride, is used as a treatment of diabetic gastroparesis or diabetic stomach stasis and prevents nausea and vomiting in patients undergoing chemotherapy. The drug is also used to help radiological tests when delayed emptying of the stomach can disrupt and when the small intestine intubation when the tube is unable to go through pylorus. The dosage requirements depend on the condition that treats this medicine. Patients with reduced renal function may require reglan® dose adjustments due to differences in speed at which they metabolize and eliminate the drug and its metabolites.
Patients receiving Reglan® to prevent nausea and vomiting associated with chemotherapy should be administered intravenously half an hour before and for at least 15 minutes. If necessary, another course, four hours, seven hours, 10 o'clock and 13 hours afterwards may be awarded. When highly nausea are used such as decarbazineOr cisplatin, Reglan® dose for the first two doses should be 2 mg per 2,2 pounds (1 kg) of body weight. A dose of 1 mg per 2.2 pounds (1 kg) may be sufficient for use with less naughty medicines. If the patient shows an acute dystonic reaction to the drug, intramuscular injections of 50 mg of dipenhydramine hydrochloride should control symptoms.
When using drugs to prevent nausea and vomiting after recovery from anesthesia, intramuscular injection should be administered at the end of the surgery. Dosage of adult Reglan® for post-surgical nausea is 10 mg. However, some patients can benefit from doses up to 20 mg.
Reglan® can be used to facilitate some lower intestinal procedures. If the delayed evacuation of the stomach prevents radiological exam for Mination, the administration of the drug with intravenous drop for two minutes may be sufficient. Adult patients should receive 10 mg reglan® dosage while patients in HDThey should receive between 2.5 and 5 mg doses for six and 14 years. The recommended Reglan® dose for patients under six years of age is 0.1 mg at 2.2 pounds (1 kg) of body weight. The same approach can be used to facilitate conventional intubation of the small intestine unless the tube has gone pylorus within 10 minutes.
These batch instructions may be necessary to revise in patients with severe renal impairment. It is defined as a creatine will (CRCL) less than 40 ml per minute. In patients with reduced liver function, reglan® dosing is not considered.