What Happens When Sodium Bicarbonate and Acid Meet in the Stomach?

[Detailed description of function]: White crystalline powder, odorless, salty, and slowly decomposes in humid air. The aqueous solution is left for a long time or heated. Sodium carbonate is generated due to the generation of carbon dioxide gas, and alkalinity is enhanced. The food industry is used as a leavening agent and acid-base regulator, and it is used as an antacid in the pharmaceutical industry. It is easy to absorb. After oral administration, it can quickly neutralize the excess gastric acid in the stomach, but the anti-acid effect is weak and the maintenance time is relatively short. Short, used for gastric hyperacidity, combined with certain sulfa drugs can prevent sulfa drugs from breaking out of crystals in the urinary tract, and combined with streptomycin for urinary tract infections, can strengthen its antibacterial effect.

Sodium bicarbonate powder

It is a white alkaline powder that is easily soluble in water. It will release carbon dioxide and CO2 when combined with water. It reacts faster in acidic liquids (if juice). As the ambient temperature rises, it releases gas. The faster it works. After baking, baking soda powder will leave sodium bicarbonate. If it is used too much, the finished product will have an alkaline taste. When baking baking soda powder is directly mixed with oil, saponification will also occur. The strong soapy taste will affect the aroma and quality of pastry. Please pay attention when using it. Baking soda is also often used as a neutralizer, such as chocolate cake. Chocolate is acidic. When used in large quantities, the pastry has a sour taste, so a small amount of baking soda powder can be used as a bulking agent and also neutralize its acidity. At the same time, baking soda powder also has the effect of darkening the color of the chocolate and making it look More "black light". Adding "excess" baking soda powder to the pasta, in addition to making the pasta have the above-mentioned result of destroying the flavor or causing too much alkaline taste, after eating, it will cause people to feel palpitations, numb lips, and temporarily lose taste.

Indications of sodium bicarbonate powder

treatment of metabolic acidosis. For mild to moderate metabolic acidosis, oral administration is appropriate. Severe metabolic acidosis should be instilled intravenously, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, extracorporeal circulation and severe primary lactic acidosis, diabetic ketoacidosis, etc.

Alkaline urine. It is used for the prevention of uric acid nephrolithiasis, reducing the nephrotoxicity of sulfa lamp drugs, and acute hemolysis to prevent hemoglobin deposition in the renal tubules.

(3) As an antacid, it treats symptoms caused by hyperacidity. ^[1]

Intravenous infusion of the iliac vein has non-specific therapeutic effects on certain drug poisoning, such as barbiturates, salicylic acid drugs, and methanol poisoning. However, this product is forbidden in gastric lavage when swallowing strong acidosis, because the product reacts with strong acid to produce a large amount of carbon dioxide, leading to acute gastric dilation and even gastric rupture.

Chemical composition of sodium bicarbonate powder

The main ingredient is sodium bicarbonate.

Pharmacological action of sodium bicarbonate powder

Treatment of metabolic acidosis, which can increase the concentration of carbonate in the plasma and neutralize hydrogen ions, thereby correcting acidosis;

Alkaline urine, due to the increase in the concentration of carbonate in the urine, the pH value increases, making it difficult for uric acid, sulfa drugs and hemoglobin to form crystals or aggregates in urine;

(3) Acid production, oral administration can quickly neutralize or buffer gastric acid without directly affecting gastric acid secretion. Therefore, the rapid increase in gastric pH relieves symptoms caused by high gastric acid.

Sodium bicarbonate powder drug interactions

Adrenocortical hormones (especially those with strong mineralocorticoid effects), adrenocorticotropic hormones, androgen are prone to hypernatremia and edema when combined.

Rhenium is used in combination with amphetamine and quinidine. The latter two have reduced renal excretion and are prone to toxic effects.

(3) Combined with anticoagulant drugs such as warfarin and M cholinesterase drugs, the latter absorption is reduced.

Combination with calcium-containing drugs, milk and dairy products can cause milk-alkali syndrome.

Combined with H2 receptor antagonists such as cimetidine and ranitidine, the absorption of the latter is reduced.

Combined with potassium excretion diuretics, increase the risk of hypochlorine alkalosis.

This product can make the urine alkaline and affect the excretion of ephedrine by the kidney, so the dose of ephedrine should be reduced when combined.

Increasing the sodium load increases the excretion of lithium by the kidney, so when combined with lithium preparations, the dosage of lithium preparations should be adjusted as appropriate.

Alkaline urine can inhibit the conversion of urotropine to formaldehyde, thereby inhibiting the latter's therapeutic effect, so it is not advisable to combine the two drugs.

The product alkalizes urine to increase excretion of salicylic acid preparation by the kidneys.

Adverse reactions of sodium bicarbonate powder

Arrhythmia, muscle cramps, pain, abnormal fatigue and weakness can occur during large injections, mainly due to hypokalemia caused by metabolic alkalosis.

When the dose is too large or there is renal insufficiency, edema, mental symptoms, muscle pain or convulsions, slowed breathing, odor in the mouth, abnormal fatigue, etc. Mainly caused by metabolic alkalosis.

(3) Long-term application can cause frequent urination, urgency, persistent headache, loss of appetite, nausea and vomiting, and abnormal fatigue and weakness. ^[2]

Contradiction of sodium bicarbonate powder

Metabolic or respiratory alkalosis;

Large amount of chlorine loss caused by vomiting or continuous gastrointestinal negative pressure suction, and metabolic alkalosis is very likely;

(3) In the case of hypocalcemia, alkalosis caused by the product may aggravate the performance of hypocalcemia.

This product is forbidden in gastric lavage when swallowing strong acidosis, because the product reacts with strong acid to produce a large amount of carbon dioxide, leading to acute gastric dilation and even gastric rupture. ^[3]