What Is an Antagonist Drug?
Antagonist, a drug that can bind to a receptor, has a strong affinity but has no intrinsic activity ( = 0). They have no effect by themselves, but antagonize the effects of agonists by occupying the receptor, such as naloxone and propranolol are antagonists. A few antagonists are mainly antagonistic, and have weak intrinsic activity ( <1), so they have weaker agonist receptors, such as oxenolol, a beta antagonist.
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- Chinese name
- Antagonist
- Foreign name
- antagonist
- Features
- Can bind to receptors
- Example
- Naloxone and propranolol
- Antagonist, a drug that can bind to a receptor, has a strong affinity but has no intrinsic activity ( = 0). They have no effect by themselves, but antagonize the effects of agonists by occupying the receptor, such as naloxone and propranolol are antagonists. A few antagonists are mainly antagonistic, and have weak intrinsic activity ( <1), so they have weaker agonist receptors, such as oxenolol, a beta antagonist.
- Antagonist: A drug that binds to a receptor and has a strong affinity without intrinsic activity ( = 0). They have no effect by themselves, but antagonize the effects of agonists by occupying the receptor, such as naloxone and propranolol are antagonists. A few antagonists are mainly antagonistic, and have weak intrinsic activity ( <1), so they have weaker agonist receptors, such as oxenolol, a beta antagonist.
- Antagonists are divided into competitive antagonists and non-competitive antagonists based on whether their binding to the receptor is reversible.
- Competitive antagonists compete with agonists for the same receptor, and their binding is reversible. When a non-competitive antagonist is used in combination with an agonist, the affinity and activity can be reduced, that is, not only the dose-effect curve of the agonist is shifted to the right, but also the maximum efficacy is reduced. It binds very strongly to the receptor, and drugs that produce irreversible binding can have similar effects.