What Is Antioxidant Therapy?

Antioxidants can reduce the damage of blood vessel walls by oxygen free radicals, thus acting as an anti-arteriosclerosis. Commonly used antioxidant drugs include vitamin E, vitamin C and so on.

Antioxidants

Antioxidants can reduce the damage of blood vessel walls by oxygen free radicals, thus acting as an anti-arteriosclerosis. Commonly used antioxidants include

Alcohol has pharmacological effects of anti-oxidation, scavenging free radicals, and affecting arachidonic acid metabolism, and has a good prevention and treatment effect on diseases such as Parkinson's disease, Alzheimer's disease, and viral hepatitis. Resveratrol has obvious protective effects on rat mitochondria caused by oxygen free radicals, can inhibit degradation of membrane phospholipids, mitochondrial swelling, increase membrane fluidity, improve mitochondrial energy metabolism, and increase antioxidant capacity 3 #, 4. Its polyphenolic hydroxyl structure has antioxidant properties, which can significantly inhibit the formation of <+> in liver microsomes, brain mitochondria, and synaptosomes. 3 ## 4 The antioxidant effect of resveratrol is one of its important mechanisms with multiple biological effects. Studies have shown that resveratrol has stronger antioxidant effects than vitamin E and vitamin C, and can scavenge free radicals, especially hydroxyl radicals, protect <+> from damage, and also inhibit the formation of glutathione disulfide , So that glutathione is in a reduced state, thereby inhibiting the formation of free radicals.

Antioxidants (AOA), also called scavengers, are a class of compounds that can inhibit or block the initiation and proliferation (spread) process of free radical chain reactions, reduce the concentration of free radicals, delay the process of sorrow, and improve vitality.

Traditional Chinese medicine has accumulated a wealth of experience in anti-aging. The experimental research and clinical application of anti-aging Chinese medicine in the prevention of free radical damage have made great progress, which is summarized below.

Ginkgo biloba leaves

Scholars at home and abroad have concluded that Ginkgo biloba extract (EGb) mainly contains physiologically active substances such as flavonoid glycosides and terpene lactones. Among them, the flavonoid molecule contains a reducing hydroxyl functional group, which acts as a hydrogen atom donor to terminate the radical chain reaction, and directly removes O2-, OH-, H2O2, alkane free radicals and lipids. This prevents and inhibits free radical reactions and lipid peroxidation reactions, and inhibits the production of active toxic substances such as serum peroxidized lipid (LPO) and its metabolites malondialdehyde (MDA) and conjugated diene. At the same time, flavonoids can also participate in regulating and increasing the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Therefore, EGB can be regarded as a broad-spectrum free radical scavenger.

Antioxidant ginseng

Ginsenosides can inhibit lipid peroxidation caused by various factors, increase SOD activity, and effectively remove O2- and OH-, can reduce the scope of experimental myocardial infarction, reduce myocardial reperfusion injury; increase cerebral blood Flow, reduce cerebral ultrastructural damage and reduce mortality; it can also significantly reduce LPO content in liver and serum of middle-aged and elderly mice, inhibit lipid peroxidation of middle-aged and elderly animals, and reduce lipofuscin deposition. Lycium barbarum Ningxia wolfberry is rich in antioxidant active substances such as carotene, vitamin E, selenium and flavonoids. The antioxidant effect is the result of the combined action of various antioxidant active substances contained in it. Lycium barbarum polysaccharide is also an important antioxidant component in wolfberry, which can significantly reduce the LPO content in spleen homogenate of experimental animals, and has a significant protective effect on lipid antioxidant damage caused by CCl4.

Ganoderma Lucidum

It is a traditional longevity medicine of traditional Chinese medicine. It not only has the function of removing O2- and OH-, but also indirectly improves the body's ability to remove oxygen free radicals.

Schisandra chinensis

Its main active ingredient is biphenylcyclooctene lignans such as Schisandrol, Schisandrin, Schisandrin and the like. Schisandra can not only play an antioxidant role by capturing oxygen free radicals, but also increase the activity of antioxidant enzymes in the cell to scavenge free radicals. The molecular mechanism of schisandra's antioxidant effect is similar to that of vitamin E (both phenolic hydroxyl groups and oxygen free radicals react on the chemical structural formula), and its effect is stronger than that of vitamin E.

Gynostemma pentaphyllum

A variety of active ingredients extracted from Gynostemma pentaphyllum have the effects of improving SOD activity, reducing monoamine oxidase (MAO-B) activity in the brain, and reducing lipofuscin accumulation, and are effective in improving symptoms of aging and treating cardiovascular and cerebrovascular diseases.

Antioxidants Panax notoginseng

Panax notoginseng saponins (PNS) can significantly reduce the plasma lipid peroxidation product MDA content in rats with acute cerebral ischemia; PNS also reduces MDA content in brain tissues and plasma of normal rats, and increases SOD activity; PNS has an effect on xanthine Oxygenase scavenges oxygen free radicals produced by purines.

Polygonum multiflorum

The decoction of this product can improve the SOD activity of whole blood in aged mice, and the ether extract can obviously inhibit the activity of MAO-B in the liver and brain. Polygonum multiflorum can also inhibit lipid peroxidation in rat liver microsomes.

Salvia miltiorrhiza

With anti-oxidant effect, it can effectively inhibit the formation of myocardial lipid peroxides during ischemia and reperfusion, can also increase the platelet SOD activity of mice, reduce the MDA content, thereby inhibit platelet aggregation and inhibit thrombosis.

Astragalus membranaceus

Experiments have shown that it has the function of resisting free radical damage, and the active extract components have a strong inhibitory effect on H2O2, O2-, and UV-induced membrane lipid peroxidation. Astragalus can also increase SOD activity, which has a two-way effect on the generation and removal of free radicals.

Antioxidants garlic

Its extract, allicin, not only has anti-tumor, antibacterial, anti-thrombolytic and anti-arteriosclerosis effects, but also has anti-free radical and brain cell protection effects. It can effectively remove O2- and OH-, and can also increase the activity of GSH-Px and CAT, reduce the production of LPO, and reduce the serum MDA level in rats with global cerebral ischemia and reperfusion.

Chuanxiong

Ligustrazine can significantly reduce LPO in tissues of rats with liver ischemia-reperfusion injury, maintain SOD activity during ischemia and reperfusion; significantly increase the activity of SOD and CAT in coronary heart disease blood, reduce MDA and LPO content, and increase blood Total mercapto groups.

Rhodiola rosea

This product is widely used in senile heart failure, anti-fatigue, improving physical and mental labor functions, is a strong antioxidant, and its effective ingredient rhodiolatine can increase the activity of SOD and GSH-Px in brain tissue and reduce LPO formation.

Mulberry parasite

This product can not only reduce lipids, but also enhance the ability to remove O2- by reducing SOD activity, reducing LPO content, protecting the biofilm, and preventing and treating atherosclerosis.

Antler

The water extract and the main active ingredients of phospholipids, total lipids and hypoxanthine can significantly inhibit the activity of MAO-B in the brain of aged mice, significantly increase the content of serotonin and dopamine in the brain, enhance the activity of SOD, and reduce MDA. Level, increase the RNA and protein content of brain tissue, and have significant protective effects on learning and memory impairment in experimental mice.

Antioxidants

The water extract of this product can significantly increase the activity of SOD and GSH-Px in the blood of rats, reduce the content of MDA, and have a significant clearance effect on lipofuscin in liver and brain tissues. Its anti-aging mechanism may be related to its antioxidant effect and Related to enhance immune function.