What Is Antiviral Therapy?

Antiviral therapy drugs refer to a group of drugs that can control the progression of the disease through the use of pharmaceutical preparations to inhibit viral replication and eventually clear the hepatitis B virus during the treatment of patients with hepatitis B.

Antiviral therapy

Antiviral therapy drugs refer to a group of drugs that can control the progression of the disease through the use of pharmaceutical preparations to inhibit viral replication and eventually clear the hepatitis B virus during the treatment of patients with hepatitis B.

Antiviral therapy is the fundamental treatment for chronic hepatitis B. Hepatitis B treatment Antiviral treatment is the key, but to know to what extent the hepatitis B virus treatment can be discontinued, a comprehensive analysis can be made after inspection to make an accurate judgment.

Chinese name

Antiviral therapy

Research object

18 to 65 years old

Detection method

By country

1.1 The study subjects selected 52 patients with HBV infection: aged 18 to 65 years, HBV-1 antibody positive by ELISA and confirmed by Westernblot results, within 14 days before

1.3 Drugs, dosages and usage

In the 52 test subjects listed in Figure 1, the test indicators were divided into three groups of eight tests. The CD4 count and viral load had significant correlations between the three groups in different treatment periods (P <0.01). Cardiac enzymes, electrolytes, hemograms, and co-infection also had different correlations in different treatment periods of the three groups of patients (P <0.05).

Figure 1 CD + 4 count and virus load after HAART.

The following three cases are clinical phenomena during antiviral treatment.

Example 1 , female, 24 years old, 8 weeks of medication, fungal culture,

When hepatitis B antiviral treatment is discontinued needs to be analyzed according to the specific situation of the patient:

1. Patients with Hepatitis B Xiaosanyang: For patients with Hepatitis B Xiaosanyang, there is no abnormal liver function, and

in

Hepatitis B antiviral treatment guidelines

Antiviral therapy is recommended for patients with hepatitis B with HBV-DNA (+) and / or HBeAg (+) and abnormal liver function, the purpose of which is to inhibit the activity and replication of HBv, reduce or inhibit the damage to liver cells, not to eliminate virus. It should be pointed out that the current antiviral treatment is not effective for HBV carriers (ie, normal liver function tests), and the incidence of cirrhosis and liver cancer in this group is extremely low. Therefore, antiviral treatment is not recommended, but liver function status must be monitored regularly in order to promptly Discover hepatitis activity. Currently proven effective antiviral drugs are: -interferon (IFN). Nucleoside analogs such as lamivudine have been widely used in clinical practice, and some nucleoside analogs such as famciclovir, adefovir, and stikavir have also been used in clinical practice. Oxymatrine is an alkaloid extracted from the plant Sophora alopecuroides, which has anti-HBV effects and has minor adverse reactions. There are currently two forms of injection and oral liquid.

The combination of antiviral therapy in the future is an inevitable trend, and there are several combinations: IFN and glycoside analogs are used in combination. At present, it has been considered that the combined treatment of HBeAg has a higher seroconversion rate than a single drug and can reduce HBv mutation. If added with traditional Chinese medicine that protects the liver and liver, the effect is better, such as compound ant nourishing liver capsules. Combined application of various nucleoside similar drugs. IFN or nucleus analogues are used in combination with immune enhancers. Domestic antiviral drugs and the above combined application.

Hepatitis C antiviral treatment guidelines

For hepatitis C, as long as the diagnosis is established, those with acute or chronic illnesses who meet the indications should be given antiviral treatment as soon as possible. The antiviral efficiency of acute hepatitis C can reach 80% -90%, which is better than hepatitis B. At present, there is no specific medicine for the treatment of hepatitis C at home and abroad. Only IFN treatment has a certain effect. It is currently considered the drug of choice for the treatment of hepatitis C. In addition, IFN plus ribavirin (RBV) combined therapy, IFN and various other immune-promoting agents such as thymosin preparations, etc., also have an effect of increasing efficacy. However, the antiviral treatment of patients with hepatitis C is less effective in the following two cases: The course of disease is more than five years, and the elderly have obvious liver tissue fibrosis and cirrhosis. Patients with chronic hepatitis B, HIv infection, and immunodeficiency. ^[2]