What is Artesunate?

ARTESUNATE (AS) is an artemisinin derivative, a natural product produced by a sweet snail, artemisia Annu . This compound is used to treat severe cases of malaria in areas where there is resistance to other antimalarial drugs. The drug that was widely used in Africa and Asia has recently received approval in the United States to treat severely ill patients who meet certain criteria. Like other medicines for the treatment of malaria, artesunate should always be used in combination with other classes of antimalarial drugs to prevent the development of parasites. Artemisinin, however, does not absorb the body well, so that derivatives have been created, including dihydroartemisinine. Artesunate is derived synthetically from dihydroartemisinin and is soluble in water. Dr.ug can be administered orally, rectally or injected into the muscles or veins. Has an active peroxide bond that reacts with red blood cells infected malaria and produces reactive oxygen species that poison the organizationsSmms inside the cell.

malaria is a serious disease that kills approximately a million people a year, especially young children. There are classic drugs that have been used for years to treat disease, especially chinin and chloroquinin. However, the parasites that cause malaria develop resistance to them. This is especially true for plasmodium Falciparum , a form of malaria that causes the most serious form of this disease. Artesunate has proved to be very useful in the treatment of serious cases of infection by this organism.

Authorities recommend using artesunate in areas in which the antem can be killed plasmodium falciparum i-malalarial drugs. The less often this compound is used, the lower the chances of developing resistance to it. Although Artesunate is very effective in removing infections, organisms tend to return and re -regret to re -circulate if it is the only medicine used intreatment. Resistance to this compound was reported in Cambodia when it was used to treat patients without other antimalary drugs. This compound is not recommended to treat cases of malaria caused by other types of plasmodium , because other drugs are still effective against these organisms.

In the United States, about 1,500 people are diagnosed each year, with approximately 10% a serious form of disease. For such patients who cannot take oral medicines, intravenous artesunate is available. Patients must also have intolerance to chinidine or organism that are infected must be resistant to this drug. From the center for D there is a special 24 -hour hot lineiseas control (CDC) to get as an emergency.