What is phosphytoin?
Podávané intramuskulární nebo intravenózní injekcí, lékaři obvykle používají fosfytoin v nemocničním prostředí pro krátkodobé léčbu zobecněných křečí a záchvatů. Surgeons can also administer drugs to prevent or stop seizures during neurosurgery. Considered to be a prick or chemical precursor, a phosphytoin sodium requires metabolic processes that naturally take place in the body to convert it into phenytoin. Treatment of epileptic seizure is usually not recommended in persons who have renal or liver disorder, as patients may take toxicity or organ damage.
After a metabolic process that converts phosphatein into phenytoin, up to 99 percent of the drug binds to plasma protein, albumin. Complete conversion after intravenous administration occurs in about two hours, while conversion after intramuscular injection may take up to four hours. Actions and effects of phosphateam generally mimic oral phenytoin pharmacologists.
As soon as it is served, phosphytoin pusObers as a sodium blocker on the surface of the nerve cells. When these channels remain open too long, too many sodium ions pass, which triggers a rapid flow of stimulating neurotransmitters. These, in turn, allow excess calcium to enter cells, causing a toxic effect that initiates varicose and seizure activity. By reducing access to sodium ion phosphytoin, it prevents the reactions of the chemical chain that contributes to cellular hyperstimulation and damage due to possible toxic conditions. The effect of the drug regulation may pose a risk to patients with certain heart conditions.
phosphatestoin usually weakens the conductive system in the heart and the chamber, worsens symptoms in patients with a heart disease and contributes to a possible life -threatening condition. In infusion, hypotension also causes a drug intravenously at sufficiently high doses. AppearanceMetabolism of drugs occurs in the liver, individuals with a decrease in hepatic damage can show jaundice, enlargement of organs and swollen lymphatic glands. Patients may also experience anemia because the drug reduces the number of red and white blood cells along with blood plates.
Healthcare providers may require periodic blood tests to monitor the number of cells, but patients should report any signs of unusual bruising or bleeding. Phosphorus is a by -product produced during phosphate metabolism that represents a risk to patients with renal impairment. The common adverse effects associated with drugs include the reaction of the injection site due to the high alkalinity of the drug. Typical reactions are also headaches, dizziness, nausea and possible vomiting. After management, individuals should carefully carefully carefully when they are or walking, as medicines could lack physical coordination.