What is Pegloticase?
Peloticase is a prescription drug used to treat the type of arthritis known as DNA. DNA is a painful condition caused when crystals of uric acid accumulate in the joints. The first line of DNA treatment is a medicine that prevents the formation of uric acid in the blood. In patients who do not respond to traditional treatment, Peloticase enzyme, which operates by transformation of uric acid into a molecule known as allantoin. Allantoin is soluble in water and is easily excreted from the body.
Gout develops when uric acid levels in blood serum increase above soluble levels. As uric acid reaches the blood saturation levels, the crystals are formed in the liquid surrounding the joints. The joints then become inflamed, which is painful and can be deactivated. DNA can evolve in any joint, but most often appear in a large finger, legs or ankle. Recurrent DNA episodes can lead to the formation of tophi or nodes in or around the joint.
traditionally, Physicians treats the day with oral regulations of alopurinol. AlLopurinol acts by preventing uric acid to prevent the blood concentration. Some patients either cannot tolerate allopurinol or do not see a reduction in symptoms with this drug. These patients may be entitled to peloticaza treatment.
Peloticase is a genetically modified form of mammal enzyme uricase. This enzyme is grown in the bacteria of Escherichia coli and after harvest it is conjugated with a molecule monomethoxypolyethylene glycol (MPEG). Monomethoxy-PEG is used to maintain the enzyme in the body to increase its efficiency. Uricase affects the distribution of uric acid after creation.
Before administration of peloticase, patients must be measured by uric acid levels in serum. The acceptable level of uric acid in serum is 6 milligrams/deciliter (mg/dl) or less. If the patient has tried other drugs and levels of uric acid, they are still too high, the doctor may prescribe peloticase. This medicine is administered by medical pRacing and is administered as intravenous infusion for two hours. Patients usually receive a dose of 8 mg Pegloticase every two weeks.
There are some side effects after peloticase infusion. Patients may have an allergic reaction at the time of administration. The symptoms of the bottom may also increase due to the release of uric acid from the tissues. Doctors seek to prevent these side effects from prescribing antihistamines and corticosteroids at least a week before the injection.