What Is Thalidomide?
Thalidomide is a glutamic acid derivative. Mechanisms of action are: sedation pain. immune regulation and anti-inflammatory effects. Inhibition of angiogenesis and anti-tumor effects: Some cytokines such as vascular endothelial growth factor and fibroblasts are stimulators of angiogenesis. They bind to specific receptors to stimulate signal transduction and cause endothelial cell proliferation. This product can reduce their secretion, thereby inhibiting blood vessels. Tumor metastasis and cell malignancy are related to adhesion of tumor cells and vascular endothelial cells, and angiogenesis. This product not only inhibits angiogenesis, but also reduces the synthesis of integrin subunits, which is also one of its antitumor mechanisms. In addition, the COX-2 pathway, rather than the pathway that inhibits angiogenesis, is also used to reduce intratumoral microvessel density, thereby preventing tumor proliferation.
Basic Information
- Chinese name
- Thalidomide
- Foreign name
- Thalidomide (Distaval)
- Character
- Light yellow crystalline powder, odorless and tasteless
- Melting point
- 269 ~ 274
Thalidomide indication
- It has a good effect on type leprosy; it can also be used for a variety of skin diseases, such as discoid lupus erythematosus, subacute cutaneous lupus erythematosus, and Behcet syndrome.
Thalidomide clinical application
- oral. 25 to 50 mg (1 to 2 tablets) at a time, 100 to 200 mg (4 to 8 tablets) a day, or as directed by your doctor.
Thalidomide adverse reactions
- This product has serious teratogenicity to the fetus. Common adverse reactions include dry mouth and nose mucosa, burnout, drowsiness, dizziness, rash, constipation, nausea, abdominal pain, facial edema, and may cause polyneuritis and allergic reactions.
Thalidomide considerations
- Be used with caution in patients with multiple myeloma, neutropenia, peripheral neuropathy, and epilepsy. The safety and effectiveness of this product for children under 12 years of age have not been established. It is not advisable to drive vehicles and operate machinery immediately after medication.
Contraindications to thalidomide
- Those who are allergic to this product are prohibited. This product can cause teratosis, pregnant women are prohibited.
Thalidomide drug interactions
- This product can enhance the effects of other central inhibitors, especially barbiturates.
- Increased risk of toxic epidermal necrolysis with dexamethasone.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.