What is the connection between tamoxifen and endometrial cancer?

Tamoxifen is a medicine commonly used to treat breast cancer. Its effects on estrogen in the human body can create an increased risk of two forms of uterine cancer. Endometrial cancer, affecting uterine lining and uterine cancer, called uterine sarcoma, becomes about 50 percent more likely after treatment with this drug. The connection between tamoxifen and endometrial cancer is one of the reasons why this uterine syndrome is the most common cancer that affects the reproductive system of women.

This drug disrupts the action of hormonal estrogen into the breast. Some types of breast cancer cells grow best in the presence of estrogen, so tamoxifen essentially prevents these cancer cells in division and growth. In other types of tissue, including uterine tissue, this medicine acts like estrogen instead of standing against it. Uterine cancer is associated with elevated estrogen levels, so the connection between tamoxifene and endometSemrakovina Rial may be related to hormonal actionIva in the uterus. Treatment of breast cancer in tumors detected soon can sometimes include up to five years of chemotherapy. This time seems to prevent the later repetition of breast cancer. However, the University of Southern California has found that the use of this drug for five or more years had a tendency to drastically increase the risk of endometrial cancer.

Normal endometrial cancer in women, according to American National Cancer Institute, it is estimated to be about 1 in 1,000. After five or more years of chemotherapy, this speed increases to about 2 in 1,000. Therefore, there is a clear correlation between tamoxifen and endometrial cancer, although the accurate mechanism by which CANCforms are not yet known.

Women using this medicine for chemotherapy should be aware of certain risk factors that can strengthen the link between tamoxifen and endometrial cancer. Researchers found estrogen sub -Stitual therapy as the University of Southern California for the only factor that has most increased the risk of uterine cancer in connection with the use of this drug. Obese women also tended to have a much greater risk of developing this type of cancer. It has been found that the use of contraceptive pills that can reduce estrogen levels in the body compensate for some of the risk of cancer that is tamoxifen.